December 2018 Volume 14, Issue 12

Volume 14, Issue 12 | December 2018

December 2018

In this Issue

Business & Government Policy

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The long and short reads of it

Illumina aims at a more comprehensive sequencing offering with the acquisition of PacBio
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Partners in immuno-oncology

MorphoSys and I-Mab sign strategic agreement for novel immuno-oncology agent MOR210
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An acquisition and a contract in infectious disease

Sobi to acquire Synagis rights from AstraZeneca for RSV; Tulane awarded NIH contract for whooping cough
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Discovery

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The two faces of AMPK

Salk scientists unravel how enzyme long thought to suppress cancer may sometimes help tumors survive
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Heal thyself—with a little boost

Sitryx and Sygnature join hands to develop therapeutics in immuno-oncology and immuno-inflammation
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Targeting tumors with TRPV6

Drug candidate minimizes cancer cell growth with minimal side effects
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Going after Parkinson’s disease with iPS cells

Keio University and Eisai open path to new techniques for developing neurological therapeutics
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Novel approaches to obesity and metabolic disease

Novo Seeds incubatee Embark Biotech enters collaboration with Novo Nordisk

Preclinical

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Innovate looking for answers about NASH

Company studies the effects of larazotide on nonalcoholic fatty liver disease
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Negating nicotine

Scripps scientists test enzyme to reduce dependence
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Heralding HERA-CD27L

Preclinical efficacy data of Apogenix compound published in Frontiers in Oncology
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Preventing heart disease in cancer survivors

CDK2 protein said to play critical role in heart damage caused by doxorubicin, a common chemotherapy drug

Feature

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Focus Feature on Cancer Research: Combating cancer with creativity

A collection of some of the newest approaches to targeting cancer cells

Commentary

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Publishers’ commentary: A year in review and a year’s preview

The publishers of DDNews check in with their annual look back and look forward for readers of the magazine and visitors of our websites
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Transparency vs. opacity

The will to understand vs. the will to obscure is not a new theme, but when blended with electronic communications it is given new intensity
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Guest Commentary: A more reproducible approach to creating functional Th17 cells

A look at the importance of Th17 cells for drug discovery and look at how the use of specialized methods to confirm cellular identity provides a level of validation that has not previously been available

Contract Services

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CROs lead industry-wide shift to modernize trial processes

Roughly nine of 10 CROs are taking steps to unify clinical operations for better visibility and improved study execution
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Advancing biomarker discovery and therapeutic development

Specialized CRO offers high-definition tissue imaging services for pharmaceutical and clinical research
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Diamond Pharma named best specialist CRO

Business award granted at OBN in recognition of expert services in cell and gene therapy

Clinical Trials

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New combo therapy for pancreatic cancer?

Pairing investigational peptide with Keytruda yields promising results for BioLineRx
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Attacking alopecia areata

Concert reveals results for drug to counter autoimmune attack against hair follicles
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LOXL2 inhibitor combats fibrosis

Pharmaxis releases positive results of Phase 1 clinical trial for second LOXL2 inhibitor compound
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Positive data for brain cancer treatment

Ziopharm provides update on Controlled IL-12 platform at Society for Neuro-Oncology meeting
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Against atrial fibrillation

GENETIC-AF Phase 2B AFB results presented at AHA 2018 meeting

Research & Development

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Fast, open and free analysis with BioJupies

Mount Sinai researchers develop tool that analyzes biomedical data within minutes
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Understanding Zika’s methods

New lab technique helps reveal how Zika virus manipulates the immune system by stripping immune cells of their identity
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A challenge for Alzheimer’s innovation

Business leader fuels global, multimillion-dollar Oskar Fischer Project

Diagnostics

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Myriad makes strides in companion diagnostics

Company announces results for ovarian cancer and an approval for breast cancer
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Digging in deep for diagnostics

Companies continue efforts to develop tests for early Alzheimer’s diagnosis
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Testing the waters in genetic screening

Nonprofits co-fund feasibility study to test screening tool for 75,000 newborns for Angelman, Prader-Willi, fragile X and Dup15q syndromes
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ThyGenX and ThyraMIR data show positive results

Interpace Diagnostics presents favorable new study findings at the 88th Annual Meeting of the American Thyroid Association
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A closer look at the tumor microenvironment 

New technologies are allowing researchers to delve deeper into the complex tumor landscape.
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Exploring stain-free western blotting

Researchers can achieve seamless western blot experiments by implementing advancements in stain-free technology, normalization methods, and compliance integration. 
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Streamlining biopharmaceutical analysis with digital solutions

Discover how digitization improves data integrity and accelerates decision-making in biotherapeutics development. 
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