December 2017- Volume 13, Issue 12
In this Issue
Research & Development
TSRI explores modified DNA nucleotides
TSRI explores modified DNA nucleotides
This repurposing of DNA to create new materials could have significant medical applications
A portal to genomic data
A portal to genomic data
First-ever genomic atlas steers the way to understanding DNA traits, diseases
Organs of interest
Organs of interest
Agilent predicts kidney toxicity; Organovo and Viscient collaborate on liver treatment
All-in-one injections
All-in-one injections
A new fabrication method out of MIT can deliver multiple biologics doses in one administration
Running the numbers
Running the numbers
Mount Sinai team reports success in using mathematical model to predict patient response to immunotherapy
Business & Government Policy
Novartis set to acquire Advanced Accelerator Applications
Novartis set to acquire Advanced Accelerator Applications
Novartis Oncology expertise to facilitate AAA’s ongoing development of theragnostic pipeline
On the cutting edge
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
Almac acquires BioClin Laboratories
Almac acquires BioClin Laboratories
Deal is expected to result in significant global expansion of existing analytical services
It’s all in the delivery
It’s all in the delivery
Checking out the news in drug delivery advancements
Preclinical
A heat shock to the system
A heat shock to the system
Esanex presents new data on SNX-5422 at international cancer conference
Path toward non-addictive painkillers
Path toward non-addictive painkillers
Researchers reportedly enhance natural pain-relief chemicals without side effects
Masitinib delivers strike to Lou Gehrig’s disease
Masitinib delivers strike to Lou Gehrig’s disease
AB Science’s preclinical data show masitinib helps peripheral nervous system in ALS
Replicating intellectual disability
Replicating intellectual disability
New mouse model will help researchers determine how abnormalities in RNA processing can lead to learning and memory impairment
Diagnostics
Enhancing digital pathology
Enhancing digital pathology
Inspirata and Elsevier team to offer ExpertPath and ImmunoQuery in diagnostic cockpit and consultation portal
Lung cancer not just smokers’ disease
Lung cancer not just smokers’ disease
ALCMI and Inivata use liquid biopsy to study ctDNA in early-stage lung cancer
Better genetic mapping for better outcomes
Better genetic mapping for better outcomes
Bionano’s Irys and Saphyr systems reportedly offer diagnostic breakthrough for genetic diseases
Discovery
Collaborating against cancer
Collaborating against cancer
New consortium to combine vast data stores, supercomputing and scientific expertise to ‘reinvent’ discovery process for cancer medicines
Taking on liver disease
Taking on liver disease
Takeda and HemoShear enter into exclusive drug discovery deal with a particular eye toward NASH
‘More shots on goal’
‘More shots on goal’
Glythera and IONTAS agree on next-generation antibody-drug conjugates
New data in war against resistance
New data in war against resistance
Collaboration develops drug candidates with antibacterial activity
On the front line of aging research
On the front line of aging research
Two TSRI initiatives tackle age-related disease
Clinical Trials
Long-term relief from psoriatic arthritis in sight
Long-term relief from psoriatic arthritis in sight
Phase 3 study on Taltz finds sustained improvements in joint pain and skin clearance in extension period
An expanded collaboration on cancer
An expanded collaboration on cancer
Boehringer Ingelheim and Sarah Cannon Research Institute broaden work into immuno-oncology
Big news for Exelixis’ MVP, Cabometyx
Big news for Exelixis’ MVP, Cabometyx
Company shares major advances for the use of cabozantinib in patients with HCC and RCC
Full speed ahead
Full speed ahead
Microsoft, PAREXEL partner to develop cloud-based solutions to accelerate drug development
Therapix advances cannabinoid pipeline
Therapix advances cannabinoid pipeline
Clinical and preclinical efforts include targeting sleep apnea, pain and infection
Special Reports
Special Report on Animal Models of Disease: I am an animal
Special Report on Animal Models of Disease: I am an animal
Non-mammalian models help personalize drug discovery
Feature
Special Focus on Cancer Research News
Special Focus on Cancer Research News
Featuring "Oncology vs. the supervillains," an article looking at several companies' recent news related to tackling some of the toughest cancers, plus a roundup of other cancer research news recently
Commentary
Publishers’ commentary: What’s in store is ‘more’
Publishers’ commentary: What’s in store is ‘more’
The publishers of DDNews take a look back and a look forward as we wind up 2017
Open access, open innovation
Open access, open innovation
What did open-access once mean in scientific literature, what does it mean now and how does it all play into innovation and the future of science?
Guest Commentary: Combinatorial screening and the future of therapeutics
Guest Commentary: Combinatorial screening and the future of therapeutics
How cell-based combinatorial cultures can improve cell bioprocessing and address future challenges in regenerative medicine
Contract Services
Ardena expands offerings
Ardena expands offerings
With acquisition of ABL, analytics and drug discovery capacity increases
On the grow
On the grow
Vetter lays the foundation for a state-of-the-art administration building
CiToxLAB purchases new facility in Montreal
CiToxLAB purchases new facility in Montreal
Move is designed to meet the growing demand for bioanalysis and biomarkers services
