December 2017- Volume 13, Issue 12

In this Issue

Business & Government Policy

Almac acquires BioClin Laboratories

Almac acquires BioClin Laboratories

Deal is expected to result in significant global expansion of existing analytical services

It’s all in the delivery

It’s all in the delivery

Checking out the news in drug delivery advancements

Novartis set to acquire Advanced Accelerator Applications

Novartis set to acquire Advanced Accelerator Applications

Novartis Oncology expertise to facilitate AAA’s ongoing development of theragnostic pipeline

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Preclinical

A heat shock to the system

A heat shock to the system

Esanex presents new data on SNX-5422 at international cancer conference

Path toward non-addictive painkillers

Path toward non-addictive painkillers

Researchers reportedly enhance natural pain-relief chemicals without side effects

Masitinib delivers strike to Lou Gehrig’s disease

Masitinib delivers strike to Lou Gehrig’s disease

AB Science’s preclinical data show masitinib helps peripheral nervous system in ALS

Replicating intellectual disability

Replicating intellectual disability

New mouse model will help researchers determine how abnormalities in RNA processing can lead to learning and memory impairment

Research & Development

A portal to genomic data

A portal to genomic data

First-ever genomic atlas steers the way to understanding DNA traits, diseases

Organs of interest

Organs of interest

Agilent predicts kidney toxicity; Organovo and Viscient collaborate on liver treatment

All-in-one injections

All-in-one injections

A new fabrication method out of MIT can deliver multiple biologics doses in one administration

TSRI explores modified DNA nucleotides

TSRI explores modified DNA nucleotides

This repurposing of DNA to create new materials could have significant medical applications

Running the numbers

Running the numbers

Mount Sinai team reports success in using mathematical model to predict patient response to immunotherapy

Clinical Trials

Big news for Exelixis’ MVP, Cabometyx

Big news for Exelixis’ MVP, Cabometyx

Company shares major advances for the use of cabozantinib in patients with HCC and RCC

Long-term relief from psoriatic arthritis in sight

Long-term relief from psoriatic arthritis in sight

Phase 3 study on Taltz finds sustained improvements in joint pain and skin clearance in extension period

Full speed ahead

Full speed ahead

Microsoft, PAREXEL partner to develop cloud-based solutions to accelerate drug development

Therapix advances cannabinoid pipeline

Therapix advances cannabinoid pipeline

Clinical and preclinical efforts include targeting sleep apnea, pain and infection

An expanded collaboration on cancer

An expanded collaboration on cancer

Boehringer Ingelheim and Sarah Cannon Research Institute broaden work into immuno-oncology

Contract Services

Ardena expands offerings

Ardena expands offerings

With acquisition of ABL, analytics and drug discovery capacity increases

On the grow

On the grow

Vetter lays the foundation for a state-of-the-art administration building

CiToxLAB purchases new facility in Montreal

CiToxLAB purchases new facility in Montreal

Move is designed to meet the growing demand for bioanalysis and biomarkers services

Diagnostics

Lung cancer not just smokers’ disease

Lung cancer not just smokers’ disease

ALCMI and Inivata use liquid biopsy to study ctDNA in early-stage lung cancer

Better genetic mapping for better outcomes

Better genetic mapping for better outcomes

Bionano’s Irys and Saphyr systems reportedly offer diagnostic breakthrough for genetic diseases

Enhancing digital pathology

Enhancing digital pathology

Inspirata and Elsevier team to offer ExpertPath and ImmunoQuery in diagnostic cockpit and consultation portal

Discovery

On the front line of aging research

On the front line of aging research

Two TSRI initiatives tackle age-related disease

New data in war against resistance

New data in war against resistance

Collaboration develops drug candidates with antibacterial activity

‘More shots on goal’

‘More shots on goal’

Glythera and IONTAS agree on next-generation antibody-drug conjugates

Taking on liver disease

Taking on liver disease

Takeda and HemoShear enter into exclusive drug discovery deal with a particular eye toward NASH

Collaborating against cancer

Collaborating against cancer

New consortium to combine vast data stores, supercomputing and scientific expertise to ‘reinvent’ discovery process for cancer medicines

Special Reports

Feature

Special Focus on Cancer Research News

Special Focus on Cancer Research News

Featuring "Oncology vs. the supervillains," an article looking at several companies' recent news related to tackling some of the toughest cancers, plus a roundup of other cancer research news recently

Commentary

Publishers’ commentary: What’s in store is ‘more’

Publishers’ commentary: What’s in store is ‘more’

The publishers of DDNews take a look back and a look forward as we wind up 2017

Open access, open innovation

Open access, open innovation

What did open-access once mean in scientific literature, what does it mean now and how does it all play into innovation and the future of science?

Guest Commentary: Combinatorial screening and the future of therapeutics

Guest Commentary: Combinatorial screening and the future of therapeutics

How cell-based combinatorial cultures can improve cell bioprocessing and address future challenges in regenerative medicine
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