December 2015 Volume 11, Issue 12

Volume 11, Issue 12 | December 2015

December 2015

In this Issue

Discovery

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Flying high with Kite and Alpine?

Kite Pharma and Alpine Immune Sciences announce research collaboration and license agreement
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New therapy for rheumatoid arthritis

Results of Compugen collaboration with Iain B. McInnes of Glasgow University presented at rheumatology meeting
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Triggering stroke recovery

UCLA researchers show role of GDF10 molecule in brain repair
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Shedding some light on the ‘dark proteome’

St. Jude’s and TSRI join with others to explore proteins in the human proteome that don’t take standard 3D structures

Business & Government Policy

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Two bigs make a giant

The $160-billion deal to combine Pfizer and Allergan would create largest pharma in the world
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AstraZeneca to acquire ZS Pharma for $2.7B

Deal brings to AstraZeneca ZS-9, which could be a best-in-class treatment for hyperkalemia
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Annexing AxioMx

Abcam acquires AxioMx, boosts antibody development capabilities
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Research & Development

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Putting two spins on oncology

Two University of Maryland spin-offs pursue anticancer therapies
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FPA008 fires things up for Five Prime

A recent deal with Bristol-Myers Squibb has a potential $1.74B price tag for Five Prime
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All about the data

Parkinson’s Institute and IO Informatics collaborate on integrated data environment
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Ultrasound delivery

Researchers at MIT and MGH enable ultra-rapid delivery of drugs to the GI tract using ultrasound waves
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Building the next generation

Parkinson’s Disease Foundation and American Parkinson Disease Association collaborate to cultivate future scientists

Feature

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SLAS2016 Show Preview: A focus on the cell

5th Annual Conference and Exhibition of the Society for Laboratory Automation and Screening (SLAS) to meet in San Diego and has added a new track focused on cellular technologies

Editor's Focus

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Looking back at 2015; walking boldly into 2016

DDNews' chief editor and publishers assess the year gone by and give a preview of what's to come in the coming year

Commentary

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Disruption interruption

Sometimes, big promises are made in pharma, biotech and the life sciences by corporations that want to succeed, but what if they aren't backed up?
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Guest Commentary: An ethical imperative to use biosimulation in drug development

By using biosimulation, pharmaceutical companies and regulatory agencies expedite bringing new, safer therapies to patients

Q&A

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Q&A: GenVec and gene-based medicine

The challenge of delivering on the promise of delivering genes as therapeutics

Clinical Trials

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Battling brachyury

Phase 1 study indicates safety and efficacy of Bavarian Nordic vaccine in advanced cancer patients
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WCG Foundation launches to spur global clinical research

Nonprofit has been established in large part to strengthen protections for research participants
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Matters of the heart

ICON partners with iCardiac on Early Precision QT program for safer drugs
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NEJM reports on Phase 3 ANNEXA studies of andexanet alfa

Full data set from ANNEXA-R also presented in late-breaking clinical trial session at AHA Scientific Sessions 2015

Diagnostics

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Pushing the personalized healthcare envelope

Human Longevity launches Health Nucleus to provide most complete picture ever of human health with genomics and more
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One method to rule them all

XRGenomics and Affymetrix collaboration aims at better testing for age-related diseases
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Rheonix rising

Ithaca, N.Y.-based Rheonix raises $28.6 million to expand commercialization efforts for its molecular diagnostic technology

Preclinical

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IMO-2125 targets tumor microenvironment

Idera presents data demonstrating potent antitumor response from combo treatment with intratumoral IMO-2125
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From candy to cancer

Calithera presents findings on potential cancer-inhibiting agent licensed from Mars Corp.
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Model behavior

Crown announces alliance focused on translational models and hosts symposia to boost discussion

Contract Services

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Leaving the nest

Metrion completes management buyout from Xention
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BioClinica launches eClinical CRO alliance program

Access to eClinical knowledge, best practices and financial benefits aims to maximize CROs’ business and scientific success
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Charles River announces new and continued drug discovery collaborations

Wellcome Trust-Funded projects expand partnerships with Charles River’s Global Discovery Services Business
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Piramal sees global sterile sales growing 10 percent annually

Rapid growth in injectables driven by pharm de-risking and biological pipeline
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Discovering deeper insights into malaria research

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