August 2019 Volume 15, Issue 8

Volume 15, Issue 8 | August 2019

August 2019

In this Issue

Business & Government Policy

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A ‘2G’ network

Gilead and Galapagos ink expansive R&D deal
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Agilent acquires BioTek

Global giant seeks to grow its live cell analysis capability
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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Evaluating new endpoints

An upcoming heart failure study will explore whether patient-centric results should be trial endpoints
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OSE receives grant from French National Research Agency

Company is to validate new targets linked to myeloid cells and identify innovative new immunotherapies in oncology

Research & Development

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Predicting in-vivo results

Hesperos’ heart-liver Human-on-a-Chip correctly determines cardiotoxic mechanisms preclinically
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Proteins in glass

Trapping proteins could help medical research
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UNC team hits bullseye with ‘magic bullet’

Researchers develop new approach to quantify antibody target occupancy in living systems
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New partnership for a new antibiotic class

Nosopharm and Evotec unite to develop antimicrobial candidates
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Mount Sinai study reveals new genetic link to heart disease

Findings may help improve risk prediction tools for cardiovascular disease

Diagnostics

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Microfluidics means minutes to sepsis diagnosis

Automated system detects early biomarker for life-threatening condition
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‘Eve of the revolution in cancer care’

Interpace purchases Biopharm Services business from Cancer Genetics
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Expanding the scope on rare diseases

Centogene publishes white paper on expansive AI database
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Advancing drug resistance testing

Quick DNA test for malaria drug resistance also holds promise for other diseases
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Precision diagnostics startup launches prenatal screen

UNITY assesses fetal risk for single-gene disorders from single tube of mother’s blood

Editor's Focus

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Editor's focus: Struggling toward a prize we may never gain

Life sciences and pharma know-how have achieved a lot, but expecting drug discovery and development to be like construction and manufacturing is asking a bit much

Commentary

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On a giant leap for mankind

As he retires from teaching at the university level (though he's not yet from retired from life sciences), columnist Peter Kissinger reflects on the past five decades of experiences and his observations of our industry
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Guest commentary: Looking at EMA’s and FDA’s topical guidelines

The regulatory landscape governing the approval of generic topical products is changing on both sides of the Atlantic, and the senior vice president of business development for MedPharm talks about what this means in terms of in-vitro release testing and in-vitro permeation testing models and other issues

Feature

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Focus Feature on Neuroscience: Intriguing approaches to Parkinson’s disease

In this feature focused on neuroscience and neurology, we look at Parkinson's disease in particular, but also explore Alzheimer's disease, artificial nervous systems, AI-based diagnostics and more
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ASHG Show Preview: Heading to Houston for human genetics

The 2019 ASHG meeting will feature the latest research on human genetics

Discovery

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Clues found to ALS progression

UCSD team reports that TDP-43 could contribute to disease progression
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A new take on norrin

Researchers explore how cellular communication and protein secretion impact hair growth
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An iPSC partnership

Fujifilm and Axcelead collaborate to advance drug discovery solutions using iPSCs
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Degrading proteins

Gilead and Nurix establish collaboration to develop novel therapies for cancer and other diseases

Preclinical

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Reldesemtiv makes strong preclinical showing

Cytokinetics’ compound was shown to improve muscle function in mice with spinal muscular atrophy
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Advancing AV-101

VistaGen has positive preclinical data supporting potential to treat levodopa-induced dyskinesia
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More on the colorectal front

Orion Biotechnology reports additional positive preclinical data for OB-002
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Of mice and rare neurological disease

JAX creates two models for Snyder-Robinson syndrome and Lixte reports progress on Angelman syndrome

Contract Services

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Multiplying models for NASH

Crown Bioscience announces four new preclinical NASH models in development
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Adding value for CDMO clients

Fujifilm completes acquisition of Biogen’s manufacturing site in Denmark
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Boosting expertise in pharmacology services

Sygnature Discovery and RenaSci strengthen in-vivo service offering

Clinical Trials

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Bipolar benefits

Lumateperone has positive Phase 3 results
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Encouraging results for endoxifen

Phase 2 study achieves primary endpoint, with topical endoxifen rapidly reducing breast density
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Cell pouch carries key to diabetes management

Sernova’s Cell Pouch System stabilized glycemic control, reduced hypoglycemic events in diabetes patients
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Straight A’s for MarzAA

Catalyst Biosciences’ FVIIa variant meets all endpoints in Phase 2 trial
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Launch into oncology

Cytodyn doses first mTNBC patient
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Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
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Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
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Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
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