August 2019- Volume 15, Issue 8
In this Issue
Clinical Trials
Launch into oncology
Launch into oncology
Cytodyn doses first mTNBC patient
Bipolar benefits
Bipolar benefits
Lumateperone has positive Phase 3 results
Encouraging results for endoxifen
Encouraging results for endoxifen
Phase 2 study achieves primary endpoint, with topical endoxifen rapidly reducing breast density
Cell pouch carries key to diabetes management
Cell pouch carries key to diabetes management
Sernova’s Cell Pouch System stabilized glycemic control, reduced hypoglycemic events in diabetes patients
Straight A’s for MarzAA
Straight A’s for MarzAA
Catalyst Biosciences’ FVIIa variant meets all endpoints in Phase 2 trial
Contract Services
Multiplying models for NASH
Multiplying models for NASH
Crown Bioscience announces four new preclinical NASH models in development
Adding value for CDMO clients
Adding value for CDMO clients
Fujifilm completes acquisition of Biogen’s manufacturing site in Denmark
Boosting expertise in pharmacology services
Boosting expertise in pharmacology services
Sygnature Discovery and RenaSci strengthen in-vivo service offering
Business & Government Policy
Agilent acquires BioTek
Agilent acquires BioTek
Global giant seeks to grow its live cell analysis capability
On the cutting edge
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
Evaluating new endpoints
Evaluating new endpoints
An upcoming heart failure study will explore whether patient-centric results should be trial endpoints
OSE receives grant from French National Research Agency
OSE receives grant from French National Research Agency
Company is to validate new targets linked to myeloid cells and identify innovative new immunotherapies in oncology
A ‘2G’ network
A ‘2G’ network
Gilead and Galapagos ink expansive R&D deal
Preclinical
More on the colorectal front
More on the colorectal front
Orion Biotechnology reports additional positive preclinical data for OB-002
Of mice and rare neurological disease
Of mice and rare neurological disease
JAX creates two models for Snyder-Robinson syndrome and Lixte reports progress on Angelman syndrome
Reldesemtiv makes strong preclinical showing
Reldesemtiv makes strong preclinical showing
Cytokinetics’ compound was shown to improve muscle function in mice with spinal muscular atrophy
Advancing AV-101
Advancing AV-101
VistaGen has positive preclinical data supporting potential to treat levodopa-induced dyskinesia
Research & Development
Mount Sinai study reveals new genetic link to heart disease
Mount Sinai study reveals new genetic link to heart disease
Findings may help improve risk prediction tools for cardiovascular disease
New partnership for a new antibiotic class
New partnership for a new antibiotic class
Nosopharm and Evotec unite to develop antimicrobial candidates
UNC team hits bullseye with ‘magic bullet’
UNC team hits bullseye with ‘magic bullet’
Researchers develop new approach to quantify antibody target occupancy in living systems
Proteins in glass
Proteins in glass
Trapping proteins could help medical research
Predicting in-vivo results
Predicting in-vivo results
Hesperos’ heart-liver Human-on-a-Chip correctly determines cardiotoxic mechanisms preclinically
Diagnostics
Expanding the scope on rare diseases
Expanding the scope on rare diseases
Centogene publishes white paper on expansive AI database
Microfluidics means minutes to sepsis diagnosis
Microfluidics means minutes to sepsis diagnosis
Automated system detects early biomarker for life-threatening condition
‘Eve of the revolution in cancer care’
‘Eve of the revolution in cancer care’
Interpace purchases Biopharm Services business from Cancer Genetics
Advancing drug resistance testing
Advancing drug resistance testing
Quick DNA test for malaria drug resistance also holds promise for other diseases
Precision diagnostics startup launches prenatal screen
Precision diagnostics startup launches prenatal screen
UNITY assesses fetal risk for single-gene disorders from single tube of mother’s blood
Editor's Focus
Editor's focus: Struggling toward a prize we may never gain
Editor's focus: Struggling toward a prize we may never gain
Life sciences and pharma know-how have achieved a lot, but expecting drug discovery and development to be like construction and manufacturing is asking a bit much
Commentary
On a giant leap for mankind
On a giant leap for mankind
As he retires from teaching at the university level (though he's not yet from retired from life sciences), columnist Peter Kissinger reflects on the past five decades of experiences and his observations of our industry
Guest commentary: Looking at EMA’s and FDA’s topical guidelines
Guest commentary: Looking at EMA’s and FDA’s topical guidelines
The regulatory landscape governing the approval of generic topical products is changing on both sides of the Atlantic, and the senior vice president of business development for MedPharm talks about what this means in terms of in-vitro release testing and in-vitro permeation testing models and other issues
Feature
Focus Feature on Neuroscience: Intriguing approaches to Parkinson’s disease
Focus Feature on Neuroscience: Intriguing approaches to Parkinson’s disease
In this feature focused on neuroscience and neurology, we look at Parkinson's disease in particular, but also explore Alzheimer's disease, artificial nervous systems, AI-based diagnostics and more
ASHG Show Preview: Heading to Houston for human genetics
ASHG Show Preview: Heading to Houston for human genetics
The 2019 ASHG meeting will feature the latest research on human genetics
Discovery
Clues found to ALS progression
Clues found to ALS progression
UCSD team reports that TDP-43 could contribute to disease progression
A new take on norrin
A new take on norrin
Researchers explore how cellular communication and protein secretion impact hair growth
An iPSC partnership
An iPSC partnership
Fujifilm and Axcelead collaborate to advance drug discovery solutions using iPSCs
Degrading proteins
Degrading proteins
Gilead and Nurix establish collaboration to develop novel therapies for cancer and other diseases
