August 2019- Volume 15, Issue 8

In this Issue

Discovery

An iPSC partnership

An iPSC partnership

Fujifilm and Axcelead collaborate to advance drug discovery solutions using iPSCs

Clues found to ALS progression

Clues found to ALS progression

UCSD team reports that TDP-43 could contribute to disease progression

A new take on norrin

A new take on norrin

Researchers explore how cellular communication and protein secretion impact hair growth

Degrading proteins

Degrading proteins

Gilead and Nurix establish collaboration to develop novel therapies for cancer and other diseases

Contract Services

Multiplying models for NASH

Multiplying models for NASH

Crown Bioscience announces four new preclinical NASH models in development

Boosting expertise in pharmacology services

Boosting expertise in pharmacology services

Sygnature Discovery and RenaSci strengthen in-vivo service offering

Adding value for CDMO clients

Adding value for CDMO clients

Fujifilm completes acquisition of Biogen’s manufacturing site in Denmark

Business & Government Policy

Agilent acquires BioTek

Agilent acquires BioTek

Global giant seeks to grow its live cell analysis capability

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Evaluating new endpoints

Evaluating new endpoints

An upcoming heart failure study will explore whether patient-centric results should be trial endpoints

OSE receives grant from French National Research Agency

OSE receives grant from French National Research Agency

Company is to validate new targets linked to myeloid cells and identify innovative new immunotherapies in oncology

A ‘2G’ network

A ‘2G’ network

Gilead and Galapagos ink expansive R&D deal

Clinical Trials

Bipolar benefits

Bipolar benefits

Lumateperone has positive Phase 3 results

Encouraging results for endoxifen

Encouraging results for endoxifen

Phase 2 study achieves primary endpoint, with topical endoxifen rapidly reducing breast density

Cell pouch carries key to diabetes management

Cell pouch carries key to diabetes management

Sernova’s Cell Pouch System stabilized glycemic control, reduced hypoglycemic events in diabetes patients

Straight A’s for MarzAA

Straight A’s for MarzAA

Catalyst Biosciences’ FVIIa variant meets all endpoints in Phase 2 trial

Launch into oncology

Launch into oncology

Cytodyn doses first mTNBC patient

Diagnostics

‘Eve of the revolution in cancer care’

‘Eve of the revolution in cancer care’

Interpace purchases Biopharm Services business from Cancer Genetics

Expanding the scope on rare diseases

Expanding the scope on rare diseases

Centogene publishes white paper on expansive AI database

Advancing drug resistance testing

Advancing drug resistance testing

Quick DNA test for malaria drug resistance also holds promise for other diseases

Precision diagnostics startup launches prenatal screen

Precision diagnostics startup launches prenatal screen

UNITY assesses fetal risk for single-gene disorders from single tube of mother’s blood

Microfluidics means minutes to sepsis diagnosis

Microfluidics means minutes to sepsis diagnosis

Automated system detects early biomarker for life-threatening condition

Preclinical

Reldesemtiv makes strong preclinical showing

Reldesemtiv makes strong preclinical showing

Cytokinetics’ compound was shown to improve muscle function in mice with spinal muscular atrophy

Advancing AV-101

Advancing AV-101

VistaGen has positive preclinical data supporting potential to treat levodopa-induced dyskinesia

More on the colorectal front

More on the colorectal front

Orion Biotechnology reports additional positive preclinical data for OB-002

Of mice and rare neurological disease

Of mice and rare neurological disease

JAX creates two models for Snyder-Robinson syndrome and Lixte reports progress on Angelman syndrome

Research & Development

Predicting in-vivo results

Predicting in-vivo results

Hesperos’ heart-liver Human-on-a-Chip correctly determines cardiotoxic mechanisms preclinically

Proteins in glass

Proteins in glass

Trapping proteins could help medical research

UNC team hits bullseye with ‘magic bullet’

UNC team hits bullseye with ‘magic bullet’

Researchers develop new approach to quantify antibody target occupancy in living systems

New partnership for a new antibiotic class

New partnership for a new antibiotic class

Nosopharm and Evotec unite to develop antimicrobial candidates

Editor's Focus

Editor's focus: Struggling toward a prize we may never gain

Editor's focus: Struggling toward a prize we may never gain

Life sciences and pharma know-how have achieved a lot, but expecting drug discovery and development to be like construction and manufacturing is asking a bit much

Commentary

On a giant leap for mankind

On a giant leap for mankind

As he retires from teaching at the university level (though he's not yet from retired from life sciences), columnist Peter Kissinger reflects on the past five decades of experiences and his observations of our industry

Guest commentary: Looking at EMA’s and FDA’s topical guidelines

Guest commentary: Looking at EMA’s and FDA’s topical guidelines

The regulatory landscape governing the approval of generic topical products is changing on both sides of the Atlantic, and the senior vice president of business development for MedPharm talks about what this means in terms of in-vitro release testing and in-vitro permeation testing models and other issues

Feature

Focus Feature on Neuroscience: Intriguing approaches to Parkinson’s disease

Focus Feature on Neuroscience: Intriguing approaches to Parkinson’s disease

In this feature focused on neuroscience and neurology, we look at Parkinson's disease in particular, but also explore Alzheimer's disease, artificial nervous systems, AI-based diagnostics and more
Subscribe to Newsletter
Subscribe to our eNewsletters

Stay connected with all the latest DDN news!

Latest Issue's Magazine Cover

Latest Issue  

• Volume 17 • Issue 2 • February 2021

February 2021

February 2021 issue