August 2018- Volume 14, Issue 8

In this Issue

Clinical Trials

‘PROMISE’-ing results against migraine

‘PROMISE’-ing results against migraine

Data demonstrate eptinezumab efficacy further improved at one year after third and fourth quarterly infusions

‘ADAPT’ or fail?

‘ADAPT’ or fail?

Biotargeting system aims to drive clinical trial success in cancer studies

Positive Phase 2 Data for bardoxolone methyl in CKD

Positive Phase 2 Data for bardoxolone methyl in CKD

Significant improvement in kidney function maintained in Alport syndrome patients after 48 weeks

Good to go with INDIGO-1

Good to go with INDIGO-1

Gemphire reports notable reductions in triglyceride levels in Phase 2b trial of gemcabene

Looking for order in chaos

Looking for order in chaos

Data integration key to faster clinical trials

Preclinical

A model that mimics

A model that mimics

New mouse model could illuminate autism subtype

Touring the oncology landscape

Touring the oncology landscape

A roundup of recent preclinical cancer research

Parkinson’s potential

Parkinson’s potential

MANF protein proves capable of protecting dopaminergic neurons, staving off motor dysfunction

A loss for liver disease?

A loss for liver disease?

Conatus Pharmaceuticals’ pan-caspase inhibitor emricasan improves survival and portal hypertension in a mouse model of cirrhosis

Discovery

Agenus discovery enhances activity of cancer-fighting antibodies

Agenus discovery enhances activity of cancer-fighting antibodies

Findings published in Cancer Cell; company’s next-generation anti-CTLA-4 antibody slated for IND in 2018

AMSBIO launches new screening company

AMSBIO launches new screening company

Joint venture with University of Strathclyde looks toward developing a new kind of microfluidics platform

Teaming up to understand single-molecule science

Teaming up to understand single-molecule science

Trio of partners seek a deeper understanding of biology and early-stage drug development

Testing therapeutic potential

Testing therapeutic potential

TSRI chemists design ‘miniecosystems’ to test drug function

Diagnostics

AI imaging

AI imaging

Progenics shares data supporting imaging analysis technology in prostate cancer

Precision medicine and pancreatic cancer

Precision medicine and pancreatic cancer

Evidence shows patients benefit from molecular profiling

New tools for Alzheimer’s

New tools for Alzheimer’s

Coalition of philanthropists commit more than $30 million for better ways to diagnose Alzheimer's disease

Can microRNA solve a big AD problem?

Can microRNA solve a big AD problem?

Researchers at Indiana University think they might be on to a simple, early test for Alzheimer's disease

Research & Development

A new bladder cancer biomarker

A new bladder cancer biomarker

Mount Sinai researchers use data science and genomics to help determine best treatment options

Methyldopa mechanism

Methyldopa mechanism

Small-molecule approach blocks autoimmunity in type 1 diabetes

An antibiotic fix with F6?

An antibiotic fix with F6?

Purdue researchers identify antibacterial compound that is less prone to antibiotic resistance

Evonetix gains £1.3M for gene synthesis project

Evonetix gains £1.3M for gene synthesis project

Innovate UK funding will support development of a novel enzymatic process for DNA synthesis

Shedding some light on the 5-8-5 scaffold

Shedding some light on the 5-8-5 scaffold

A new approach from FSU could help researchers unlock a promising but hard to synthesize molecular structure

Business & Government Policy

For your approval

For your approval

A collection of recent regulatory approvals and other actions globally

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Attacking arthritis

Attacking arthritis

University of Birmingham forms spinout to develop new therapeutic target for RA

Making progress

Making progress

A roundup of recent pharma/biotech milestones

Contract Services

CDMO invests in ‘solid’ growth

CDMO invests in ‘solid’ growth

JPS announces major investment and facility expansion, focused on oral solid dose manufacturing

A new mouse for Deerfield

A new mouse for Deerfield

Acquisition of Ablexis sets stage for market expansion with AlivaMab Mouse and founding of AlivaMab Discovery Services

Novacap completes acquisition of PCI

Novacap completes acquisition of PCI

With the purchase, the company expands its pharmaceutical offerings in the U.S.

Q&A

Q&A: GigaGen growth and the NIH

Q&A: GigaGen growth and the NIH

GigaGen CEO discusses how NIH programs and funding help early-stage companies such as GigaGen get up and running, providing support in clinical and commercial spheres

Special Reports

Special Report on Drug Delivery: Penetrating the impenetrable

Special Report on Drug Delivery: Penetrating the impenetrable

Researchers are working hard to find novel and interesting ways to overcome problems of getting across the blood-brain barrier

Feature

Show Preview: Basel Life/EMBO

Show Preview: Basel Life/EMBO

Lively times ahead at Basel Life, as the annual congress gets set to bridge the worlds of science and business, focusing on European life sciences

Editor's Focus

Editor’s Focus: Science isn’t always friendly, but it isn’t the enemy

Editor’s Focus: Science isn’t always friendly, but it isn’t the enemy

Somewhere along the line, it became sort of "popular" to denigrate science and scientists, and it's time to turn that trend around

Commentary

Listening to the chemistry talk

Listening to the chemistry talk

Medicine is moving decade by decade to be more information-rich and constrained by the resulting increases in cost from advances in both the physics and the chemistry; the tools in the black bag of 1960 are not enough for today’s best result
Guest Commentary: How genomic testing is redefining cancer research

Guest Commentary: How genomic testing is redefining cancer research

Guest Commentary: How genomic testing is redefining cancer research

Improved genomic sequencing techniques are increasing the rigor of the clinical development process and genomic profiling is helping to identify new therapeutic targets as well as biomarkers of treatment response
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