August 2013 Volume 9, Issue 8

Volume 9, Issue 8 | August 2013

August 2013

In this Issue

Global News

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AstraZeneca acquires Pearl Therapeutics to strengthen respiratory portfolio

Acquisition could be worth $1.15 billion, all told
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From Russia with drugs

Russian pharmaceutical giant Pharmstandard extends global reach with Bever acquisition
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GSK follows Genentech in partnering with Immunocore

Companies to develop ImmTACs to treat cancer, viral disease
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Flipping the vaccine script

EU-funded consortium seeks to develop ‘fully personalized’ cancer vaccines for brain cancer patients
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Navigating the maze of the mind

UCB and Lieber Institute collaborate to discover new medicines for brain disorders

Research & Development

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Building a biologics boom

Fifth-generation anticancer biologics poised to enter $120-billion market
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Making monoclonal antibodies for multiple myeloma

Germany’s MorphoSys, Celgene sign pact to develop novel therapeutic antibody for patients with blood cell cancer
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Flexing their muscles

Cytokinetics, Astellas explore novel-mechanism skeletal muscle activators
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Optimizing optides

Blaze Bioscience, Hutchinson Center ink option agreement
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Attacking autoimmune disease

Adaptive Biotechnologies signs deal with Biogen Idec to characterize immune status of patients with autoimmune disease

Omics & Systems Biology

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The sum of the whole

International partners describe global alliance to enable secure sharing of genomic and clinical data
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U.K.’s Department of Health launches DNA mapping effort

Genomics England will lead effort aimed at a better understanding of cancer, rare and infectious diseases
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Dibs on DUBs

FORMA Therapeutics partners with Cancer Research Technology to discover cancer drug candidates against deubiquitinating enzymes
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New sickle cell treatment now in beta-globin

UCLA researchers set to advance gene therapy into clinical trials
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Off to see the wizard

John Theurer Cancer Center joins hands with Genewiz to advance ovarian cancer biomarker discovery

Clinical Trials

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Managing the pain of clinical trials

Cross-disciplinary groups seek ‘gold standard’ in measurement of subjective patient outcomes in clinical trials for pain medications
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Tackling cancer in Tennessee

SCRI, AstraZeneca to develop oncology compounds, focus on molecular profiling
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A landmark for AD

FDA and EMA vet Critical Path Institute’s clinical trial simulation tool for Alzheimer’s disease
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A blockbuster of a trade

Amgen and Servier exchange commercialization rights across continents
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Targeting tumors

Loxo Oncology, Array BioPharma partner on small- molecule drugs for cancer

Commentary

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Oncology outsourced: An emerging research model

Outsourcing makes our scientific world flat; a citizen scientist with limited resources can now do projects previously restricted to a large pharmaceutical company with enormous resources.
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Facts don’t matter … until they do

I am grumpy because I now understand why Sen. Daniel Patrick Moynihan said, “You are entitled to your opinion. But you are not entitled to your own facts.”

Editor's Focus

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On which side of the pond is the grass greener?

As the U.K. is contemplating privatizing the NHS, we’re moving toward a national healthcare system. It all makes me wonder: On which side of the pond is the grass greener?

Products & Services

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A 3D InSight into drug discovery with Tecan’s Infinite M200 PRO

A novel solution for analyzing 3D cell cultures, based on Tecan’s Infinite M200 PRO and InSphero’s 3D InSight microtissue technology, is helping to reduce the cost of early-phase drug development.

Tools & Technology

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Leica Biosystems acquires Kreatech Diagnostics

Kreatech will join Leica Biosystems’ Advanced Staining Business Unit based in Newcastle-upon-Tyne, U.K.
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Zeiss in 3D

Longtime leader in light and electron microscopy acquires Xradia’s 3D X-ray microscope business
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Best in metabolomics class

AB SCIEX, Genedata & LECO form partnership for cross-platform metabolomics data analysis solution
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ELNs and first-to-file

Electronic lab notebooks are no longer just replacing paper, but enabling collaboration around the globe with IP protection

Special Reports

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Model citizens

Stem cells’ promise of disease-in-a-dish opens doors to truly personalized medicine
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Model citizens (continued)

Stem cells’ promise of disease-in-a-dish opens doors to truly personalized medicine

Diagnostics

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A ‘sea change’ in the desert

Arizona-based TGen and Ventana join forces to meet demand for diagnostic cancer biomarkers from pharma and regulators
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Keeping an eye on oral cancer

Texas A&M, MD Anderson seek to promote early detection in oral cancer
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Thermo Fisher Scientific, Newman-Lakka Institute pursue personalized cancer treatment

Partnership will focus on developing methods to track circulating biomarkers in blood
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Partners in precision--not just personalized--medicine

Janssen, Mt. Sinai researchers take the lead in IBD research
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Advancing immuno-oncology research with cellular assays

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