August 2013- Volume 9, Issue 8

August 2013

In this Issue

Global News

Flipping the vaccine script

Flipping the vaccine script

EU-funded consortium seeks to develop ‘fully personalized’ cancer vaccines for brain cancer patients

Navigating the maze of the mind

Navigating the maze of the mind

UCB and Lieber Institute collaborate to discover new medicines for brain disorders

From Russia with drugs

From Russia with drugs

Russian pharmaceutical giant Pharmstandard extends global reach with Bever acquisition

Omics & Systems Biology

U.K.’s Department of Health launches DNA mapping effort

U.K.’s Department of Health launches DNA mapping effort

Genomics England will lead effort aimed at a better understanding of cancer, rare and infectious diseases

Dibs on DUBs

Dibs on DUBs

FORMA Therapeutics partners with Cancer Research Technology to discover cancer drug candidates against deubiquitinating enzymes

New sickle cell treatment now in beta-globin

New sickle cell treatment now in beta-globin

UCLA researchers set to advance gene therapy into clinical trials

Off to see the wizard

Off to see the wizard

John Theurer Cancer Center joins hands with Genewiz to advance ovarian cancer biomarker discovery

The sum of the whole

The sum of the whole

International partners describe global alliance to enable secure sharing of genomic and clinical data

Clinical Trials

Tackling cancer in Tennessee

Tackling cancer in Tennessee

SCRI, AstraZeneca to develop oncology compounds, focus on molecular profiling

A landmark for AD

A landmark for AD

FDA and EMA vet Critical Path Institute’s clinical trial simulation tool for Alzheimer’s disease

A blockbuster of a trade

A blockbuster of a trade

Amgen and Servier exchange commercialization rights across continents

Targeting tumors

Targeting tumors

Loxo Oncology, Array BioPharma partner on small- molecule drugs for cancer

Managing the pain of clinical trials

Managing the pain of clinical trials

Cross-disciplinary groups seek ‘gold standard’ in measurement of subjective patient outcomes in clinical trials for pain medications

Diagnostics

A ‘sea change’ in the desert

A ‘sea change’ in the desert

Arizona-based TGen and Ventana join forces to meet demand for diagnostic cancer biomarkers from pharma and regulators

Keeping an eye on oral cancer

Keeping an eye on oral cancer

Texas A&M, MD Anderson seek to promote early detection in oral cancer

Special Reports

Model citizens

Model citizens

Stem cells’ promise of disease-in-a-dish opens doors to truly personalized medicine

Model citizens (continued)

Model citizens (continued)

Stem cells’ promise of disease-in-a-dish opens doors to truly personalized medicine

Research & Development

Making monoclonal antibodies for multiple myeloma

Making monoclonal antibodies for multiple myeloma

Germany’s MorphoSys, Celgene sign pact to develop novel therapeutic antibody for patients with blood cell cancer

Flexing their muscles

Flexing their muscles

Cytokinetics, Astellas explore novel-mechanism skeletal muscle activators

Optimizing optides

Optimizing optides

Blaze Bioscience, Hutchinson Center ink option agreement

Attacking autoimmune disease

Attacking autoimmune disease

Adaptive Biotechnologies signs deal with Biogen Idec to characterize immune status of patients with autoimmune disease

Building a biologics boom

Building a biologics boom

Fifth-generation anticancer biologics poised to enter $120-billion market

Products & Services

A 3D InSight into drug discovery with Tecan’s Infinite M200 PRO

A 3D InSight into drug discovery with Tecan’s Infinite M200 PRO

A novel solution for analyzing 3D cell cultures, based on Tecan’s Infinite M200 PRO and InSphero’s 3D InSight microtissue technology, is helping to reduce the cost of early-phase drug development.

Tools & Technology

Leica Biosystems acquires Kreatech Diagnostics

Leica Biosystems acquires Kreatech Diagnostics

Kreatech will join Leica Biosystems’ Advanced Staining Business Unit based in Newcastle-upon-Tyne, U.K.

Zeiss in 3D

Zeiss in 3D

Longtime leader in light and electron microscopy acquires Xradia’s 3D X-ray microscope business

Best in metabolomics class

Best in metabolomics class

AB SCIEX, Genedata & LECO form partnership for cross-platform metabolomics data analysis solution

ELNs and first-to-file

ELNs and first-to-file

Electronic lab notebooks are no longer just replacing paper, but enabling collaboration around the globe with IP protection

Commentary

Oncology outsourced: An emerging research model

Oncology outsourced: An emerging research model

Outsourcing makes our scientific world flat; a citizen scientist with limited resources can now do projects previously restricted to a large pharmaceutical company with enormous resources.

Facts don’t matter … until they do

Facts don’t matter … until they do

I am grumpy because I now understand why Sen. Daniel Patrick Moynihan said, “You are entitled to your opinion. But you are not entitled to your own facts.”

Editor's Focus

On which side of the pond is the grass greener?

On which side of the pond is the grass greener?

As the U.K. is contemplating privatizing the NHS, we’re moving toward a national healthcare system. It all makes me wonder: On which side of the pond is the grass greener?
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