April 2020 Volume 16, Issue 4
Volume 16, Issue 4 | April 2020
April 2020
In this Issue
Preclinical
A new method for modified NK cells
GEMoaB publishes preclinical proof-of-concept data on UniCAR-modified off-the-shelf natural killer cellsA ‘shock and kill’ approach
Combo therapy could produce long-term HIV remission even without ARTWorking toward a broad-spectrum therapy
Ocugen’s gene therapy candidate shows potential in five different models of retinitis pigmentosaResearch & Development
A consortium against COVID
The newly established COVID-19 Genomics UK Consortium unites government, public health and research organizations to conduct sequencing studies of the virus and its transmissionBoning up on HSCs
Mount Sinai researchers use stem cells to improve bone marrow transplantationAstrocytes, Alzheimer’s and autism
Location of cells in the brain could determine neurological disordersShank3 and hypersensitivity
New study may help people with autismDigging into diabetes
Researchers are gaining new insights into the mechanisms behind diabetesFeature
Focus Feature: COVID-19/SARS-CoV-2
Coverage of efforts to develop vaccines against the virus, research on potential therapeutics for COVID-19 and work being conducted on diagnostics to detect SARS-CoV-2 infectionClinical Trials
MS highs and lows in the clinic
Companies see progress and setbacks as they advance therapeutic candidates against multiple sclerosisOne step at a time
Results of CDNF trial take Herantis a step closer to possible cure for Parkinson’s diseaseAI on the attack
Biofourmis’ remote monitoring platform may provide new insights to fight COVID-19Datacubed offers tech free for virtual COVID-19 studies
Advanced mHealth technology firm offers study teams identification solutions in real-timeUnder the umbrella
Cytel touts basket and umbrella trial designDiscovery
Putting all your experiments in one basket
Purdue team develops collapsible basket array to speed compound screeningA new company takes aim at MS
Pheno Therapeutics is targeted toward treatments for multiple sclerosisMolecular fishing
Technique finds and measures individual molecules in blood
Entering a discovery-stage collaboration
BI and Trutino Biosciences to explore cancer immunology with novel cytokine platformAnswering questions about APA
Researchers shine light on how regulatory mechanism impacts pancreatic cancerEditor's Focus
New class of drug conjugate
Avacta combines two of its proprietary tools to create TMACs against cancerEditor’s Focus: In this industry, we must stand strong against COVID-19
There have been challenges and missteps in the handing of the COVID-19 pandemic and now is the time for all parties (academic, private, governmental and otherwise) to step up and show commitment and compassionContract Services
Working toward a COVID vaccine
Organizations combine strengths to address outbreak pathogens, including novel coronavirusSpaulding awarded contract with FDA
Multiple clinical trials will address a variety of therapeutic areasBusiness & Government Policy
Three-way deal focuses on new ways to beat cancer
Phio Pharmaceuticals and Helmholtz Zentrum München to collaborate with MedigeneOn the cutting edge
A roundup of instrumentation, software and other tools and technology newsA new holding for Catalent
MaSTherCell acquisition to complement and strengthen company’s gene therapy offeringsEppendorf acquires centrifuge business from Koki
Company says deal makes it a global full-line provider of high-performance premium centrifugesPatent Docs: The question of expert testimony in patent cases
Patent Docs' Kevin Noonan talks about the potential peril of using a layperson to provide expert testimonyDiagnostics
Adipose-ing a solution
Visceral fat can predict liver fibrosis and fibrosis progression in people with HIVCan microbes diagnose cancer?
Researchers seek to improve on liquid biopsy trend and less-invasive oncology diagnosticsMindful of the babies
InfanDx to develop diagnostics for newborns at risk for cerebral palsy, other brain injuriesSpecial Reports
Special Report on Neuroscience: On good behavior
To translate to humans, neurobehavioral models must first translate to animalsCommentary
Metrics gone wild: Biomarkers that don’t mark
Counting publications is appealing in its simplicity and we all do that. The capacity for words and numbers no longer depends on paper and ink; a consequence of this system (for biomarkers and other research) may well relate to irreproducible scientific papers going viral, often from the most prestigious journalsGuests Commentary: The importance of the pharmaceutical composition analyzer
An accurate analyzer can provide simultaneous analysis of entire composition of samples for precision and security
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Explore how validated fluid biomarker assays advance clinical research for neurological diseases.
Understanding drug impurities: types, sources, and analytical strategies
Unseen and often unexpected, drug impurities can slip in at every drug development stage, making their detection and control essential.
Discovering cutting-edge nitrosamine analysis in pharmaceuticals
New tools help researchers detect and manage harmful nitrosamine impurities in drugs such as monoclonal antibodies.
