April 2019- Volume 15, Issue 4

In this Issue

Diagnostics

A meeting of the minds at multiscale

A meeting of the minds at multiscale

Olympus, USC pair up to leverage a host of technologies to accelerate precision medicine in cancer

A ‘Mammoth’ licensing victory

A ‘Mammoth’ licensing victory

Mammoth Biosciences gains license to Cas14 CRISPR protein, completing its diagnostic toolbox

Molecular makeup

Molecular makeup

Researchers aim to determine likelihood of breast cancer recurrence

Biocartis and Bristol-Myers Squibb sign deal

Biocartis and Bristol-Myers Squibb sign deal

Collaboration will focus on MSI testing related to immuno-oncology therapies

Research & Development

Scholar Rock picks SRK-181

Scholar Rock picks SRK-181

Company aims to develop cancer immunotherapy candidate, which is a selective inhibitor of TGFβ1 activation

Bioinformatics infrastructure finds funding

Bioinformatics infrastructure finds funding

UKRI has awarded infrastructure funding to support the open data resources provided by EMBL-EBI

Dementia diagnosis; dementia difference

Dementia diagnosis; dementia difference

Race can mean dramatic differences in pathologies, and new research seeks to delve into that

Cancer clue in cellular machinery

Cancer clue in cellular machinery

Florida researchers say potential avenue for cancer treatment could be hiding in microscopic ‘molecular machine’

Cancer clue in cellular machinery

Cancer clue in cellular machinery

Florida researchers say potential avenue for cancer treatment could be hiding in microscopic ‘molecular machine’

Building a new toolbox

Building a new toolbox

University at Buffalo lab receives NIH grant to develop tools for an inside look at cells’ responses to drugs

Contract Services

Launch time

Launch time

A roundup of recent new offerings from contract services organizations

Axiom awarded multiple contracts

Axiom awarded multiple contracts

Studies will use Fusion eClinical Suite’s IWRS Module

A match made in the cloud

A match made in the cloud

New alliance seeks to change and improve patient recruitment and trial participation

Crowning the rodents

Crowning the rodents

CrownBio strikes deals with Charles River for rats and JAX for mice

Preclinical

Summit seeks a much-needed superdrug

Summit seeks a much-needed superdrug

Company explores candidates against antimicrobial-resistant bacteria

Synthetic sebum

Synthetic sebum

Mouse model mimics human acne

Glauconix completes cannabinoid pilot study

Glauconix completes cannabinoid pilot study

Study confirms intraocular pressure-lowering effects, proving promising novel treatment for glaucoma

The point of the spear: Targeting MAGE-A4

The point of the spear: Targeting MAGE-A4

Adaptimmune presents preclinical data for its next-generation SPEAR T cell

Clinical Trials

MorphoSys reports ‘MIND’-bending results

MorphoSys reports ‘MIND’-bending results

MOR208 clinical trial results promising and drug is on fast track to FDA approval, company says

Challenging Chagas

Challenging Chagas

Bayer's efforts to advance nifurtimox against Chagas disease bear fruit in successful Phase 3 trial

Strongbridge shares SONICS study results

Strongbridge shares SONICS study results

Extended evaluation phase meets objective of showing positive long-term benefit-risk profile of Recorlev

Hear ye, hear ye

Hear ye, hear ye

Auris Medical announces publication of AM-111 Phase 3 results for inner ear hearing loss

TransCon hGH scores with superiority

TransCon hGH scores with superiority

Once-weekly growth hormone demonstrates superiority on primary endpoint compared to daily growth hormone in Phase 3

Discovery

Mining microbiomes

Mining microbiomes

Seres Therapeutics, AstraZeneca to explore the interaction of the microbiome and immunotherapies

AbCellera acquires multiple multiyear deals

AbCellera acquires multiple multiyear deals

Company collaborates with Novartis, Denali Therapeutics and the Bill & Melinda Gates Foundation

Merck and Iktos collaborate on compounds

Merck and Iktos collaborate on compounds

Agreement grants Merck KGaA access to Iktos’ AI technology across three drug discovery projects

Business & Government Policy

Biogen buys into ophthalmology

Biogen buys into ophthalmology

Company announces agreement to acquire Nightstar Therapeutics

A ‘continuous’ need

A ‘continuous’ need

Continuous manufacturing embraced by FDA and researchers

No pain and a gain

No pain and a gain

Pacira acquires MyoScience and its non-opioid pain therapy ioveraº

Special Reports

Special Report on Neuroscience: Holding out hope

Special Report on Neuroscience: Holding out hope

In this special report, we explore how scientists are reframing the conversation around therapeutic approaches to depression

Editor's Focus

Editor’s focus: Shining light on depression?

Editor’s focus: Shining light on depression?

Does a new treatment specifically targeting postpartum depression signal new progress in other niche areas of depression as well as treating the illness more broadly?

Commentary

Small molecules need love too

Small molecules need love too

There are plenty of new areas to explore in therapeutic options for all diseases and conditions that vex us, but are we straying too far from reliable ground and ignoring good options in the process?

Guest Commentary: Targeting α-synuclein and the pathogenesis of Parkinson’s disease

Guest Commentary: Targeting α-synuclein and the pathogenesis of Parkinson’s disease

Discovery of antibodies highly selective for toxic α-synuclein conformations may require more than just classical methods if pharma and life sciences want to make faster progress against Parkinson's disease

Feature

Show Preview: Immunology 2019 heads to San Diego

Show Preview: Immunology 2019 heads to San Diego

The American Association of Immunologists brings its educational and other programming to the West Coast

Q&A

Q&A: Modeling the microenvironment

Q&A: Modeling the microenvironment

A newly developed tumor model could offer better accuracy
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