April 2019 Volume 15, Issue 4
Volume 15, Issue 4 | April 2019
April 2019
In this Issue
Research & Development
Building a new toolbox
University at Buffalo lab receives NIH grant to develop tools for an inside look at cells’ responses to drugsScholar Rock picks SRK-181
Company aims to develop cancer immunotherapy candidate, which is a selective inhibitor of TGFβ1 activationBioinformatics infrastructure finds funding
UKRI has awarded infrastructure funding to support the open data resources provided by EMBL-EBIDementia diagnosis; dementia difference
Race can mean dramatic differences in pathologies, and new research seeks to delve into thatCancer clue in cellular machinery
Florida researchers say potential avenue for cancer treatment could be hiding in microscopic ‘molecular machine’Cancer clue in cellular machinery
Florida researchers say potential avenue for cancer treatment could be hiding in microscopic ‘molecular machine’Clinical Trials
TransCon hGH scores with superiority
Once-weekly growth hormone demonstrates superiority on primary endpoint compared to daily growth hormone in Phase 3MorphoSys reports ‘MIND’-bending results
MOR208 clinical trial results promising and drug is on fast track to FDA approval, company saysChallenging Chagas
Bayer's efforts to advance nifurtimox against Chagas disease bear fruit in successful Phase 3 trialStrongbridge shares SONICS study results
Extended evaluation phase meets objective of showing positive long-term benefit-risk profile of RecorlevHear ye, hear ye
Auris Medical announces publication of AM-111 Phase 3 results for inner ear hearing lossContract Services
Crowning the rodents
CrownBio strikes deals with Charles River for rats and JAX for miceA match made in the cloud
New alliance seeks to change and improve patient recruitment and trial participationLaunch time
A roundup of recent new offerings from contract services organizationsAxiom awarded multiple contracts
Studies will use Fusion eClinical Suite’s IWRS ModuleSpecial Reports
Special Report on Neuroscience: Holding out hope
In this special report, we explore how scientists are reframing the conversation around therapeutic approaches to depressionEditor's Focus
Editor’s focus: Shining light on depression?
Does a new treatment specifically targeting postpartum depression signal new progress in other niche areas of depression as well as treating the illness more broadly?Commentary
Small molecules need love too
There are plenty of new areas to explore in therapeutic options for all diseases and conditions that vex us, but are we straying too far from reliable ground and ignoring good options in the process?Guest Commentary: Targeting α-synuclein and the pathogenesis of Parkinson’s disease
Discovery of antibodies highly selective for toxic α-synuclein conformations may require more than just classical methods if pharma and life sciences want to make faster progress against Parkinson's diseaseFeature
Show Preview: Immunology 2019 heads to San Diego
The American Association of Immunologists brings its educational and other programming to the West CoastQ&A
Q&A: Modeling the microenvironment
A newly developed tumor model could offer better accuracyDiscovery
Mining microbiomes
Seres Therapeutics, AstraZeneca to explore the interaction of the microbiome and immunotherapiesAbCellera acquires multiple multiyear deals
Company collaborates with Novartis, Denali Therapeutics and the Bill & Melinda Gates FoundationMerck and Iktos collaborate on compounds
Agreement grants Merck KGaA access to Iktos’ AI technology across three drug discovery projectsPreclinical
Summit seeks a much-needed superdrug
Company explores candidates against antimicrobial-resistant bacteriaSynthetic sebum
Mouse model mimics human acneGlauconix completes cannabinoid pilot study
Study confirms intraocular pressure-lowering effects, proving promising novel treatment for glaucomaThe point of the spear: Targeting MAGE-A4
Adaptimmune presents preclinical data for its next-generation SPEAR T cellDiagnostics
A ‘Mammoth’ licensing victory
Mammoth Biosciences gains license to Cas14 CRISPR protein, completing its diagnostic toolboxMolecular makeup
Researchers aim to determine likelihood of breast cancer recurrenceA meeting of the minds at multiscale
Olympus, USC pair up to leverage a host of technologies to accelerate precision medicine in cancerBiocartis and Bristol-Myers Squibb sign deal
Collaboration will focus on MSI testing related to immuno-oncology therapiesBusiness & Government Policy
Biogen buys into ophthalmology
Company announces agreement to acquire Nightstar TherapeuticsA ‘continuous’ need
Continuous manufacturing embraced by FDA and researchersNo pain and a gain
Pacira acquires MyoScience and its non-opioid pain therapy ioveraº
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Discovering deeper insights into malaria research
Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite’s complex lifecycle and global burden.
Accelerating RNA therapeutic testing with liver microphysiological platforms
Researchers can now study oligonucleotide delivery and efficacy in a system that models a real human liver.
