April 2018- Volume 14, Issue 4

In this Issue

Q&A

Q&A: Pharnext and Pleotherapy

Q&A: Pharnext and Pleotherapy

French biopharma addresses neurodegenerative diseases, combining low doses of existing drugs to develop treatments for new indications using big data analysis

Commentary

Theranos: Lessons learned

Theranos: Lessons learned

A company that makes too many promises it cannot keep and doesn't even surround itself with scientific experts probably shouldn't be in the life-sciences business

Guest Commentary: Preclinical studies gain the edge with syngeneic models

Guest Commentary: Preclinical studies gain the edge with syngeneic models

Syngeneic mouse models are employed extensively in early-stage drug discovery and have become a workhorse for one of the fastest-growing areas of research, immuno-oncology, transforming how investigators approach novel therapies

Business & Government Policy

Advancing from the acquisition

Advancing from the acquisition

RNA hybridization, multiplex assays central to Bio-Techne’s growth plans in wake of acquiring Advanced Cell Diagnostics

It’s all in the delivery

It’s all in the delivery

Checking out the news in drug delivery advancements

NIH completes in-depth genomic analysis of 33 cancer types

NIH completes in-depth genomic analysis of 33 cancer types

Researchers funded by the National Institutes of Health have completed a detailed genomic analysis, known as the PanCancer Atlas

V ClinBio forges clear path to FDA

V ClinBio forges clear path to FDA

Acquires equity stake in Cellix Bio and its Synergix drug delivery program; partners with Camargo

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Clinical Trials

Curing HBV for good

Curing HBV for good

Curing HBV for good

Spring Bank takes combinatorial approach to hepatitis B virus

Informa teams up with Saama on trials

Informa teams up with Saama on trials

Aim is to leverage AI to offer customers a complete understanding of the clinical trial landscape

A new weapon in the opioid struggle

A new weapon in the opioid struggle

Opiant announces development of intranasal nalmefene for treatment of opioid overdose

Reducing cancer recurrence with BPX-501

Reducing cancer recurrence with BPX-501

Bellicum reports encouraging results in pediatric patients with primary immunodeficiencies

Diagnostics

Xpresys Lung 2 lances lung cancer

Xpresys Lung 2 lances lung cancer

Test identifies benign lung nodules with high probability to avoid unnecessary invasive procedures

Advancing cancer immunotherapy

Advancing cancer immunotherapy

Personal Genome Diagnostics expands its tumor mutational burden patent portfolio

Telix and Radboud seal clinical collaboration agreement

Telix and Radboud seal clinical collaboration agreement

Work will focus on several clinical projects in relation to imaging diagnostics for cancer

Faster pathway through proteomics?

Faster pathway through proteomics?

A recently completed study supports the value of multiplexed mass spectrometry tests for diagnosing lung cancer and pre-term births

Discovery

Linking up for bacteria libraries

Linking up for bacteria libraries

Deinove granted access to Naicons’ bacterial strain library in search of new antibiotics

Stem cell promise for kidney disease

Stem cell promise for kidney disease

CD133 revealed as a potential target for encouraging kidney repair

Glutamate and its role in addiction

Glutamate and its role in addiction

Indiana University-led study finds neurotransmitter glutamate may play a role in alcohol relapse, addiction

Research & Development

Patient-on-a-Chip progresses

Patient-on-a-Chip progresses

Organ-on-a-chip tech recreates human intestinal lining; program launched to test chips in treatment selection

Sulfones at Scripps

Sulfones at Scripps

A new cross-coupling simplifies the synthesis of drug-like molecules

All about antibodies

All about antibodies

Merger marries cutting-edge research players

Cellular chariots

Cellular chariots

TSRI researchers link cellular cargo transport machinery to neurological disorders

Oral peptide availability at last?

Oral peptide availability at last?

TUM team details a method for designing peptide agents with oral availability and intestinal permeability

Preclinical

Organogold antibiotics

Organogold antibiotics

Auspherix gets Innovate UK grant to explore therapeutic for difficult infections

Obsidian advances destabilizing domains

Obsidian advances destabilizing domains

Company presents data demonstrating its CAR-T platform for safer, more effective cancer treatments

Targeting TGFβ

Targeting TGFβ

Research team identifies a hormone that prevents colon cancer from responding to immunotherapy

Argos obtains option to license PD1 checkpoint inhibitors

Argos obtains option to license PD1 checkpoint inhibitors

Data have shown synergy between PD1 checkpoint inhibition and analogue of Rocapuldencel-T in preclinical renal carcinoma model

The truth about TREM2

The truth about TREM2

Brain’s immune system may be key to new Alzheimer’s treatments

Contract Services

CAR-T manufacturing potential moves to Asia

CAR-T manufacturing potential moves to Asia

With half of CAR-T studies in China, Cesca looks to capitalize on market potential with CDMO expansion

Speeding the flow with downstream conjugation

Speeding the flow with downstream conjugation

ADC Bio introduces new method for antibody-drug conjugate manufacture

HemaCare and Charles River aim to accelerate drug discovery and development

HemaCare and Charles River aim to accelerate drug discovery and development

PBMC humanization kits for NCG mouse models are said to facilitate infectious disease and immuno-oncology research

Editor's Focus

NIH needs more, not less

NIH needs more, not less

Can we please stop talking about cutting the National Institutes of Health budget; it's just about one of the last things we need right now (or ever)

Special Reports

Special Report on Neuroscience: Beyond ‘reefer madness’

Special Report on Neuroscience: Beyond ‘reefer madness’

Companies and academic researchers work to convert Cannabis self-pharmacy to science
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