April 2016- Volume 12, Issue 4

April 2016

In this Issue

Discovery

Taking on the undruggables

Taking on the undruggables

PhoreMost and Wistar seek to de-orphan new targets in oncology, aging and immunology

Compugen seeks to usher in ‘new era’ in oncology

Compugen seeks to usher in ‘new era’ in oncology

Company identifies binding partner for CGEN-15029 and moves closer to IND filing

Not your Jedi’s ‘LIGHTSABR’

Not your Jedi’s ‘LIGHTSABR’

Scripps Florida researchers develop a cheap, portable drug discovery system

Peptides for immunology and immuno- oncology

Peptides for immunology and immuno- oncology

New biotech startup focuses on next generation therapeutic peptides in oncology, immuno-oncology and immune diseases

Microbiome magic

Microbiome magic

Synlogic-AbbVie collaboration to use synthetic biotics to develop IBD drug

Research & Development

Breaking membrane barriers

Breaking membrane barriers

Microfluidic device could quicken DNA insertion into bacteria

Cobra strikes with CPI to advance regenerative medicines

Cobra strikes with CPI to advance regenerative medicines

UK’s Cobra Biologics and CPI join hands to develop industrial manufacturing platform, advance regenerative medicines

Boosting research on organisms

Boosting research on organisms

DNASTAR releases Lasergene 13 software to enhance RNA research

TSRI and JCVI scientists call stem cell techniques ‘safe’

TSRI and JCVI scientists call stem cell techniques ‘safe’

New research indicates the act of creating iPSCs for clinical use is unlikely to pass on cancer-causing mutations to patients

RNA and HIV

RNA and HIV

In exploring methylation in HIV, researchers uncover a key to its replication

Contract Services

A partner for Phase 3

A partner for Phase 3

Actinium selects Medpace as CRO for pivotal Iomab-B clinical trial

Synexus expands to U.S.

Synexus expands to U.S.

The U.K. SMO has acquired Dallas-based Research Across America

Crown to commercialize prostate cancer models

Crown to commercialize prostate cancer models

University of York’s unique collection of PDX models to be applied to drug development

Preclinical

Improving on CIK CAR-T

Improving on CIK CAR-T

Formula and Rockland collaborate to develop C.I.K. CAR pipeline for cancer

Relief from Rett?

Relief from Rett?

Study suggests Phase 2 Alzheimer’s drug could treat rare Rett syndrome

Pancreatic cancer vaccine shows promise

Pancreatic cancer vaccine shows promise

OncoQR’s TYG100 elicits strong immune response in all treated individuals

Much-improved mouse models

Much-improved mouse models

Taconic addresses cross-species issues to create mouse model with human-like immune system

Diagnostics

Age more than just a number in breast cancer

Age more than just a number in breast cancer

Screening for breast cancer needs to consider age, suggests new study

Promise of personalized medicine

Promise of personalized medicine

Invivoscribe-Thermo collaboration seeks to help diagnose blood malignancies

New findings on fungal asthma

New findings on fungal asthma

A multi-organization team identifies 19 genetic variants related to susceptibility and damage risk

CTE diagnostic test studied in NFL players

CTE diagnostic test studied in NFL players

Recent developments may allow for chronic traumatic encephalopathy to be tested in live humans

Business & Government Policy

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

For your approval

For your approval

A collection of recent regulatory approvals and other actions globally

A ‘Blueprint’ for success for cancer immunotherapy

A ‘Blueprint’ for success for cancer immunotherapy

Roche and Blueprint Medicines collaborate to combine former’s cancer immunotherapy expertise with latter’s drug discovery platform and immunokinase expertise

Spark Therapeutics acquires Genable Technologies

Spark Therapeutics acquires Genable Technologies

Spark adds new program for leading cause of inherited retinal disease

Clinical Trials

Fighting degenerative disease

Fighting degenerative disease

Mesoblast develops portfolio of mesenchymal cells to target multiple medical needs

1 DNA Way paves way to FDA

1 DNA Way paves way to FDA

The Lancet publishes Genentech study on Actemra for remission in patients with giant cell arteritis

A different kind of toolkit

A different kind of toolkit

MRCT team develops Ethics Tool Kit as guidelines for clinical research protocols

ALZ-801 poised for next step against Alzheimer’s

ALZ-801 poised for next step against Alzheimer’s

Alzheon announces efficacy analyses of prior tramiprosate Phase 3 studies on key clinical endpoints in Alzheimer’s disease

ViiV announces Phase 2 results for injectable regimen for HIV-1 treatment

ViiV announces Phase 2 results for injectable regimen for HIV-1 treatment

32-week maintenance data at Conference on Retroviruses and Opportunistic Infections showed comparable viral suppression between injectable regimen and three drug oral regimen

Editor's Focus

Gene genie dilemma?

Gene genie dilemma?

We don’t need to put genomics ‘back in the bottle,’ but we may need to bottle up expectations

Commentary

Phenotype beats genotype; measurements beat guessing

Phenotype beats genotype; measurements beat guessing

Have we entered into such a love affair with the promise of genetic data that we've unfairly and unwisely begun to neglect things like basic chemistry?

Guest Commentary: New frontiers for target ID in oncology--Where will the next generation of targets come from?

Guest Commentary: New frontiers for target ID in oncology--Where will the next generation of targets come from?

Cancer therapy is fast approaching a clinical crossroads: to treat a cancer patient with an approach based on stimulating an immune response or to target the cancer cells directly with cytotoxic or a targeted therapy?

Special Reports

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