April 2015- Volume 11, Issue 4

April 2015

In this Issue

Diagnostics

Dual assay for developing world and beyond

Dual assay for developing world and beyond

Rheonix gets $1.5-million grant to complete development of point-of-care HIV/AIDS test

Plaque Array method links blood plaque components to Alzheimer’s

Plaque Array method links blood plaque components to Alzheimer’s

Study on Plaxgen Alzheimer’s disease blood diagnostic published in peer-reviewed journal

Biocept launches liquid biopsy option

Biocept launches liquid biopsy option

Blood-based EGFR detection method can help identify who would benefit from certain NSCLC therapies

Pairing up for precision medicine

Pairing up for precision medicine

Merck Serono, Illumina to collaborate on universal NGS-based cancer diagnostic

Preclinical

Rexahn’s RX-5902 shows its mettle

Rexahn’s RX-5902 shows its mettle

Preclinical data show that Supinoxin’s mechanism of action decreases expression of several oncogenes

Algae, mosquitoes and herd immunity

Algae, mosquitoes and herd immunity

UCSD School of Medicine researchers discover malaria vaccine candidate, but funding sources dry up

Right to the bone

Right to the bone

N8 drug combo may promote osteogenesis and prevent Staphylococcus aureus infection

Preclinical data published on fast skeletal muscle troponin activator

Preclinical data published on fast skeletal muscle troponin activator

Rat model suggests possible effectiveness in treating heart failure-related exercise intolerance

Discovery

Adimab enters bispecific antibody deal with Sanofi

Adimab enters bispecific antibody deal with Sanofi

Sanofi will have the rights to all therapeutic antibodies and bispecifics resulting from the collaboration

Together on a QUEST

Together on a QUEST

Cyclenium Pharma brings QUEST Library to multidrug-resistant infection collaboration with Fundación MEDINA

Re-Pharm finds new use for old drug

Re-Pharm finds new use for old drug

Antibiotic shows novel anti- inflammatory activity after five decades in service against noninflammatory conditions

Putting a hurt on neuropathic pain

Putting a hurt on neuropathic pain

UC Davis researchers identify carboline compound that could lead to drugs to prevent neuropathic pain syndromes

Clinical Trials

A trio advancing trials

A trio advancing trials

Taking a look at three recently announced technologies aimed at making clinical trials run more effectively

Kicking the habit

Kicking the habit

Merger makes Catalyst public and advances clinical trial goals, while ending Targacept’s nicotine R&D

MetAP2 mettle

MetAP2 mettle

Zafgen releases promising clinical results for obesity drug beloranib

On to Phase 3 for ADHD clinical trial

On to Phase 3 for ADHD clinical trial

Alcobra’s MDX meets primary endpoint in Phase 2 trial in adolescents with attention deficit hyperactivity disorder

Research & Development

A solid partnership

A solid partnership

Freeslate to combine HTS tech with CIRCE’s predictive software to address solid state issues

GPS against cancer cells

GPS against cancer cells

Kite Pharmaceuticals is trying to change the landscape of immunotherapy

Does team of TG and Checkpoint mean checkmate in oncology?

Does team of TG and Checkpoint mean checkmate in oncology?

Immuno-oncology deal between the two companies targets hematological malignancies

Horizon Discovery to support Cancer Research UK program

Horizon Discovery to support Cancer Research UK program

Horizon’s Diagnostics division will provide genetically defined, human genomic reference standards to Stratified Medicine Programme

Machinery of the mind

Machinery of the mind

TSRI discoveries shed light on neurodegenerative disorders, including research on ‘molecular motor’

Business & Government Policy

Valeant acquires Salix for more than $11 billion

Valeant acquires Salix for more than $11 billion

Addition of U.S. company to Canadian company’s collection of acquisitions gives Valeant a GI boost

Power of combining

Power of combining

Bristol-Myers Squibb signs agreement with Bavarian Nordic for PSA-targeting cancer immunotherapy

Advancing mRNA in vaccination

Advancing mRNA in vaccination

The Bill & Melinda Gates Foundation and CureVac collaborate on vaccine technology

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Imagining a future with Imbruvica

Imagining a future with Imbruvica

AbbVie pays $21 billion for Pharmacyclics, nets promising cancer therapy

Q&A

Q&A: Berg works to ‘put Dallas back in North Texas’

Q&A: Berg works to ‘put Dallas back in North Texas’

DDNews speaks with Dr. Niven R. Narain, co-founder, president and chief technology officer of Berg, about his company's Interrogative Biology platform, AI and predictive modeling, Big Data and bringing more actual cures to patients instead of just relief

Feature

Massing in Missouri for mass spec

Massing in Missouri for mass spec

The American Society for Mass Spectrometry heads to St. Louis for its 2015 annual meeting

Special Reports

Editor's Focus

Tech, tock; tech, tock…how long until we reveal all?

Tech, tock; tech, tock…how long until we reveal all?

So much of our personal information is out there for consumption by corporate interests and others; new movements to use wearable tech to enhance life-sciences research and clinical trials mean your vitals might be added to that data collective, though it still may be for the best in the end

Commentary

Djerassi, spring break and mass spectrometry

Djerassi, spring break and mass spectrometry

Find out a bit about why Carl Djerassi is such a big deal and also why mass spectrometry means so much to life sciences generally and drug discovery and development as well

Commentary: Precision medicine is not just about genetic testing

Commentary: Precision medicine is not just about genetic testing

Leveraging science and technology to prevent and treat diseases based on our individual biological makeup is a potentially transformative approach that will enable us to deliver healthcare more effectively and efficiently than we ever thought possible, and one of the technological keys to that is LC-MS
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