April 2014- Volume 10, Issue 4

April 2014

In this Issue

Research & Development

Edison and Dainippon ink nearly $4.3 billion deal

Edison and Dainippon ink nearly $4.3 billion deal

Strategic alliance targets drugs to treat cellular energy metabolism

Mediators for immune-mediated disease

Mediators for immune-mediated disease

Sanofi, UCB team up to develop anti-inflammatory small molecules

True game changer?

True game changer?

Idea of creating stem cells by exposing them to acid has people talking

IDBS partners with Osthus on R&D IT

IDBS partners with Osthus on R&D IT

New alliance to deliver improved efficiency and workflows

Backing BACE inhibitors

Backing BACE inhibitors

Eisai, Biogen Idec pair up for potential Alzheimer’s treatments

Discovery

Overcoming antibiotic resistance

Overcoming antibiotic resistance

Technical University of Munich chemists unleash two new weapons in the battle against MRSA and tuberculosis

Game changer

Game changer

Berg and the Parkinson’s Institute collaborate on biomarker discovery

Bringing genomics into natural products discovery

Bringing genomics into natural products discovery

NIGMS to fund research that will use genomic and metagenomic sequencing data to find natural products

Smash and grab

Smash and grab

Scripps researchers develop two novel ways to discover new drugs

Clinical Trials

Putting their heads together

Putting their heads together

Key players across neuro- oncology community gather to build action plan for brain tumor imaging practices

Merck HIV therapies make big news at CROI

Merck HIV therapies make big news at CROI

Company gives a peek at a new drug and shares a study for an old favorite

Miracle in the desert?

Miracle in the desert?

Ben Gurion University collaborates with the University of Colorado on potential type 1 diabetes cure

Aiming to defeat HIV

Aiming to defeat HIV

Argos Therapeutics’ Arcelis technology creates patient-specific immunotherapy targeted toward eradicating AIDS

Making clinical trials more diverse

Making clinical trials more diverse

Various players in the healthcare industry unite to launch ‘I’m In’ campaign

Diagnostics

A relationship reaches a crescendo

A relationship reaches a crescendo

Myriad Genetics to acquire Crescendo Bioscience for $270 million

Scoring in the 90s

Scoring in the 90s

Cancer Genetics cites compelling diagnostic sensitivity and accuracy for its patent-protected genomic kidney cancer test

New link in cancer care chain

New link in cancer care chain

Cholesterol metabolism study suggests new diagnostic, treatment approach for aggressive prostate cancer

MetaStat announces new U.S. patent for MetaSite Breast

MetaStat announces new U.S. patent for MetaSite Breast

Reportedly the first Dx that directly detects and quantifies mechanisms by which metastatic cells disseminate through blood to cause secondary tumors

Chembio receives CE Mark approval for rapid POC detection of HIV

Chembio receives CE Mark approval for rapid POC detection of HIV

Chembio Diagnostics Inc. announced in March that its HIV 1/2 STAT-PAK Assay received CE Mark approval from European regulators

Global POC Diagnostics Market to Grow at a CAGR of 9.3 percent to 2018

Global POC Diagnostics Market to Grow at a CAGR of 9.3 percent to 2018

According to a new report from Research and Markets, the global point-of-care (POC) diagnostics market will grow at a compound annual growth rate (CAGR) of 9.3 percent to 2018

Preclinical

Helping hands and hepatocytes

Helping hands and hepatocytes

EMD Millipore and Promethera team up to develop liver assay

The immune (r)evolution in cancer

The immune (r)evolution in cancer

Heat Biologics presents preclinical data comparing ImPACT-based immunotherapy with vaccines and T cell co-stimulators at Keystone Symposia

Merry news for Merrimack

Merry news for Merrimack

Preclinical results for cancer compound published in Molecular Cancer Therapeutics

Immunicum advances adoptive immunotherapy

Immunicum advances adoptive immunotherapy

Company reports promising preclinical results for its CD70 technology, which may provide a robust method to expand tumor-specific T cells with improved quality

In Vitro ADMET Laboratories and Taconic announce alliance to offer humanized and knock-out mouse hepatocytes

In Vitro ADMET Laboratories and Taconic announce alliance to offer humanized and knock-out mouse hepatocytes

In Vitro ADMET Laboratories LLC (IVAL) and Taconic announced an agreement in late March under which IVAL will prepare cryopreserved hepatocytes derived from Taconic’s knockout and genetically humanized mouse models for use in preclinical drug development research
HPV eradicated by AHCC supplement, preclinical study suggests

HPV eradicated by AHCC supplement, preclinical study suggests

HPV eradicated by AHCC supplement, preclinical study suggests

According to research coming out of the the University of Texas Health Science Center (UTHealth) Medical School at Houston, a Japanese mushroom extract called active hexose correlated compound (AHCC) may have a role in prevention of human papillomavirus (HPV)-related cancers.

Business & Government Policy

The little engine that could

The little engine that could

Janssen’s Autism Search Engine aims to drive cutting-edge research

Pharmacyclics: First drug gets rolling

Pharmacyclics: First drug gets rolling

Company follows 2013 Imbruvica approval with accelerated approval for another indication

A matter of aesthetics

A matter of aesthetics

KYTHERA acquires rights to ATX-101 outside of the U.S. and Canada from Bayer Consumer Care

Social media easing into a role in clinical research

Social media easing into a role in clinical research

However, a problem that needs addressing is fragmentation and uncoordinated use

Special Reports

Out of Africa: Special report on point-of-care diagnostics

Out of Africa: Special report on point-of-care diagnostics

Developing world diagnostic solutions might make emerging markets merging markets

Q&A

Q&A: The ‘odd couple’ of Alzheimer’s disease and schizophrenia

Q&A: The ‘odd couple’ of Alzheimer’s disease and schizophrenia

Alzheimer’s disease and schizophrenia are not often linked in the same sentence, much less in the same scientific conversation, but in an interview with DDNews, Dr. Deborah Dunsire, president and CEO of Forum Pharmaceuticals, and her colleague Dr. Lon S. Schneider at USC tell us why perhaps they should be

Editor's Focus

Pharmas assemble! Up and away! Or something

Pharmas assemble! Up and away! Or something

It's easy to pick on the pharma and biotech companies and paint them as heartless, money-grubbing opportunists. But the truth is a bit more complex, and both the public and government need to update the way they look at things.

Commentary

My war on poverty

My war on poverty

Taking a slight detour from the world of pharma and biotech, DDNews columnist Peter T. Kissinger lays out his plan to win the war on poverty that was ushered in during the 1960s and has struggled ever since.

Commentary: Automation—The answer to tedious manual sample preparation for mass spectrometry?

Commentary: Automation—The answer to tedious manual sample preparation for mass spectrometry?

Mass spectrometry (MS) technology has advanced extremely rapidly over the last decade, with MS techniques now being widely used in life science research, and even finding their way into the clinical setting for diagnostic applications. As one of the first sectors to adopt MS technology, the drug discovery market has been at the forefront of this revolution and, as such, has now become one of the first areas of research to run up against the major limitation of the technique—sample preparation.
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