Biologic drug development involves complex challenges related to protein stability, aggregation, and manufacturability. Early characterization of conformational and colloidal stability can help researchers identify promising candidates, optimize formulations, and reduce downstream development risks. Analytical approaches that measure unfolding, self-association, and particle behavior provide valuable insight into how biologics respond to different conditions throughout development.
This compendium explores how biophysical characterization methods can be applied throughout biologics development workflows to assess conformational stability, aggregation behavior, and formulation performance.
Download this compendium to learn:
- How stability measurements support biologics candidate selection
- Key parameters to evaluate protein unfolding, aggregation, and self-interaction
- Why biophysical characterization supports formulation and preclinical assessment
