High-throughput in-vivo CNS pharmacology screening

 

High-throughput in-vivoCNS pharmacology screening provides rapid, tailor-made lead validation serviceusing selected in-vivo and ex-vivo assays. Locomotor activity,catalepsy test, MRI Imaging and supportive PK and receptor occupancy assaysreveal PK/PD dynamics of new molecules with administration routes fromtraditional to systemic and brain IT/ICV/IP. Endpoint sampling for tissue,plasma and CSF enables additional mechanistic characterizations.