Proteins vary over time in response to changes in lifestyle, medication, health, and disease. Yet, traditional proteomics tools lack the sensitivity and robustness to detect individual protein changes and simultaneously characterize global proteome fluctuations.
Download this poster from SomaLogic to discover a powerful proteomics platform that detects subtle protein changes and profiles the global proteome using just a few microliters of biological fluid.
Next Generation Proteomics
High-Plex Biomarker Discovery
Protein Biomarkers
Protein biomarker discovery plays an important role in advancing precision medicine. Protein levels vary over time and change in response to many factors, including lifestyle and medication. Circulating proteins in biological fluids provide clues into the molecular dynamics of health, disease, and treatment response. Yet, traditional proteomics tools lack the robustness to characterize global proteome profiles and simultaneously detect high and low abundant proteins.
High-Plex Protein Profiling
The SomaScan® Assay, a high throughput multiplexed proteomics assay, fills this technology gap. Using this assay, scientists can measure 7,000 proteins from 55 µl of serum, plasma, or other biological fluid. The assay utilizes multiwell plates and automation, allowing for high throughput processing of over 1,000 samples per day. High affinity protein binding of modified DNA aptamers known as SOMAmer® reagents underlies the assay’s sensitive protein detection power.
High Affinity SOMAmer Reagents
SOMAmer reagents are chemically synthesized single stranded DNA molecules that recognize and bind specific human protein epitopes. The unique qualities of SOMAmer reagents enable highly specific protein detection from the fmol to µmol scale. Each unique SOMAmer reagent consists of a specific DNA aptamer with modifications for enhanced binding specificity, a fluorophore, a photocleavable linker, and a biotin molecule.
Driving Drug Discovery Forward
Scientists apply the SomaScan Assay across numerous fields to discover protein biomarkers and pathways implicated in neurodegeneration, cancer, diabetes, and other diseases. The assay’s sensitivity, specificity, reproducibility, and broad detection range allow scientists to measure dynamic changes in protein levels over time, validate novel biological targets, and evaluate drug responses and efficacies across different patients to advance precision medicine.