CRISPR-based screens for drug discovery

Genome-wide CRISPR screens in living organisms reveal mechanisms that cell culture studies overlook.

CRISPR-based screens are powerful genetic tools for identifying genes associated with disease development or drug resistance. Traditionally, scientists have performed CRISPR genome-wide screenings using in vitro cell culture systems due to the complexities of applying CRISPR in living organisms, such as sufficiently delivering CRISPR components to all cells. In this webinar, Kristin Knouse will discuss a novel method to perform CRISPR screenings within the livers of living mice.

Topics to be covered

  • Establishing genome-wide CRISPR screening in the mouse liver
  • Applying high-throughput functional genomics in any mouse cell type 

Monday, August 28th, 2023 | 2:30 PM - 3:30 PM Eastern Time
This webinar will be available to view live and on demand.


Kristin Knouse, MD, PhD

Kristin Knouse, MD, PhD

Whitehead Career Development Professor
Massachusetts Institute of Technology

Supported by