Digital illustration of a human liver with branching vessels, depicted as a glowing hologram made of interconnected points and lines on a dark background.

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Unexpected liver toxicity is one of the most common reasons drugs fail in development or are withdrawn after approval. Standard lab and animal models often miss these risks because they cannot fully capture the complexity of the human liver. Microphysiological systems (MPS) offer a way forward by recreating human liver biology in the lab, providing richer insights into how drugs behave and why toxic effects occur.Download this compendium to learn:<ul><li>How advanced liver MPS reveal toxicity signals that conventional tests often overlook</li><li>What these systems uncover about the biological pathways behind liver injury</li><li>Ways researchers can use MPS to better predict clinical outcomes and improve drug safety decisions</li></ul>

CN Bio is a leading organ-on-a-chip (OOC) company based in Cambridge, UK. CN Bio offers a portfolio of products and services to optimise the accuracy and efficiency of bringing new medicines to market; providing significant savings in cost and time to drug discovery and development pipelines.With more than a decade of experience in precision engineering and single and multi-organ microphysiology, CN Bio aims to transform the way human-relevant pre-clinical data is generated through the development of advanced, predictive human organ models. The Company&rsquo;s PhysioMimix&reg; OOC range of microphysiological systems (MPS) bridges the relevance gap between traditional cell culture, in vivo animal studies, and human trials by advancing towards the simulation of human biological conditions. The technology provides deep mechanistic insights to enable researchers to refine preclinical study design, reducing the number of animals required, and better preparing and informing studies ahead of the clinic to support safe, efficacious and efficient therapeutic development.

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CN Bio

Microphysiological systems capture the complexity of human liver biology, addressing one of drug development&rsquo;s most persistent challenges.

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Closing the gap in liver toxicity testing

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Compendium

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Microphysiological systems capture the complexity of human liver biology, addressing one of drug development’s most persistent challenges.

Closing the gap in liver toxicity testing

Microphysiological systems capture the complexity of human liver biology, addressing one of drug development’s most persistent challenges.

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