Currently available Chromobodies trace importantcellular processes like cell cycle, apoptosis, DNA damage and repair, or even allowcytoskeletal analysis. The Cell Cycle Chromobody cell line that has been licensedby Bayer traces the complete cell cycle in real-time in live cells "in anon-invasive manner while providing full flexibility to multiplex with otherprocedures," ChromoTek indicates, with ChromoTek's head of R&D, Dr. KouroshZolghadr, adding, "We are pleased to offer our customers efficient tools forachieving more detailed and physiologically relevant information on the effectsof drug candidates on cell cycle progression."
Established in 2008 as a spin-off from Munich's
Ludwig Maximilian University and located in Martinsried, which is Germany'sleading biotech hubr, ChromoTek develops and markets Chromobody-based live-cellassays for drug screening and target validation. Other products includeimmunological and bioimaging reagents, such as the GFP-Trap for the rapidpull-down of GFP fusion proteins, GFP and RFP Booster to amplify fluorescencesignals of GFP or RFP fusion proteins. ChromoTek's newly developedfluorescence-based protein-protein interaction assay calledFluorescent-2-Hybrid (F2H) is available as a development service.
