Neuroscience

Cancer anywhere in the body can change brain activity, and brain activity can drive cancer growth. These surprising discoveries are leading to new treatments.

A new porcine model for the rare neurological disorder CLN3 Batten disease more faithfully recreates human symptoms and could accelerate drug development.

Slight modifications to glycoproteins reveal critical insights into disease onset, state, and progression, making them a wellspring for biomarker discovery. 

Researchers identified a peptide that selectively blocks pain signaling in sensory neurons and packaged it into a viral-based gene therapy in a step towards treating chronic pain without the risk for addiction.

Although harmful in large quantities, hydrogen sulfide may ameliorate the health consequences of aging when small doses are applied to the mitochondria.

An allosteric inhibitor may block glutamate’s toxic effects in the brain without affecting healthy synaptic neurotransmission.

The blood-brain barrier seems impenetrable, but new therapeutic antibodies may creep past its defenses. 

A small molecule called ALGERNON2 improved health outcomes in mouse models of neurodegenerative diseases by activating antioxidant pathways in astrocytes.

With ongoing advances, NMR spectroscopy remains a unique tool for unraveling the structural secrets of proteins.

Molecules that promote restoration of the neuron’s myelin sheath could offer a reparative therapy for multiple sclerosis.

Researchers explore the role of forgetting in normal brain function and as a therapeutic target for fear-related disorders.

Inducing the expression of antioxidant genes offers hope for alleviating severe facial discomfort in patients with a chronic pain condition.