Structural analysis of the herpes simplex virus polymerase revealed that mutations affecting its drug binding and flexibility may drive treatment resistance.
Profiling over 100,000 genomes, researchers identified rare mutations associated with early menopause and cancer, and that some mutations pass down to children.
A new technique boosts the sensitivity of mass cytometry to allow detection and characterization of low-abundance markers, yielding new disease insights.
As global regulations shift toward animal-free testing, how can researchers develop more biologically relevant in vitro models to advance drug discovery?