Dr. William E. Rich
Articles by Dr. William E. Rich

| 6 min read
The conventional approaches used to discover biomarkers that can be used to help us understand disease and assay for its presence or response to drug treatment represent a wonderful start. They involve looking at differential biology at the protein level and trying to see if there are changes, racing to sequence all of the changes, and then going back to the literature or reconciling with one’s own hypotheses to choose which of the changed proteins are really relevant to the clinical question you are asking. Whatever the clinical question, whether it is detection of disease, determining the likelihood of response or an adverse reaction to a drug, you have to choose the right biomarkers and then build reproducible, precise assays.
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