Valeant and Ardea also have a research agreement under whichArdea is undertaking preclinical work on an epilepsy drug for Valeant. Ardeastands to earn $3.5 million annually for the research, with the possibility ofreceiving milestones and renewal of the one-year term. Zhi says Ardea has apreclinical group and infrastructure that supports, among other things,researching drug metabolism and toxicity, preformulation, formulation andanimal studies. "We do have all the little things that a typical discovery [or]pure research company doesn't have," he says.
For Zhi, who calls drug discovery and research his passion,the appeal of Ardea is the opportunity to move compounds from their beginningstages through commercialization in one company. Zhi and Quart both seessynergies between Ardea's capabilities and the Valeant programs, with Quartciting "great opportunity of taking some interesting research technology andputting it together with very solid, very experienced development people."Quart and Kimberly Manhard, Ardea's senior vice president of regulatory affairsand operations, have resumes that cover drug trials and approvals. The appeal of Valeant's programs was driven partly bymarket opportunities for HIV and cancer drugs, says Quart, and Ardea'sinterests in those indications go beyond Valeant candidates. Though he couldnot provide details, Quart says Ardea will consider other targets inindications with large returns on investment. "One of the things about workingin a small biotech environment that's different from a large pharma is it isreally important to be in targets that are either validated or easilyvalidatable."
Quart likes antivirals because drug value is clearafter simple phase 2a studies, making trials efficient. He has high hopes forMEK inhibitors, such as Ardea's AR119, which Ardea hopes will enter Phase 1clinical trials in 2007. Observers of Ardea, says Quart, can expect to see aNASDAQ relisting and "some pretty strategic acquisition to support ourinterests, particularly in antivirals." That suits Zhi, who claims a strongbackground working with hepatitis C and HIV: "The company has a strategy," hesays. "Obviously, we're all very strong in the antiviral space."
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