| 2 min read
Register for free to listen to this article
Listen with Speechify
0:00
2:00
SANTA CLARA, Calif.—Agilent Technologies Inc. and AppliedProteomics Inc. have joined forces to collaborate on highly multiplexed proteinassays and workflow solutions for multiple-reaction monitoring via massspectrometry. The partnership unites Agilent's vast product offering inmeasurement tools and mass spectrometry equipment with Applied Proteomics'proteomics platform solution, which is based on computational expertise andmass spectrometry-based systems control.
 
 
"We are thrilled to be collaborating with AppliedProteomics, an organization that has leading expertise in developing massspectrometry-based methods and instrumentation technologies for proteinquantification and proteome applications," Can Ozbal, director of Agilent'sRapidFire business, said in a press release. "Agilent's innovative automation,measurement and software platforms transform complete workflow solutions fromsample preparation through data acquisition, analysis and evaluation inquantitative proteomics and biomarker validation."
 
In this undertaking, Applied Proteomics will make use ofAgilent's 6490 Triple Quadrupole MS/MS, 1290 Infinity LC, RapidFire 360 MSsystem and Bravo liquid-handling technologies in order to optimize throughputin highly multiplexed proteomic assays. No financial terms regarding thecollaboration were disclosed.
 
"The ability to quickly and accurately measure, monitor andanalyze a large number of protein biomarkers in a single test has importantapplications for understanding human diseases and developing new clinicaldiagnostics. Agilent's innovation in mass spectrometry is an important part ofthis collaboration as we work together to expand the capabilities of multiplexprotein assays," John E. Blume, Ph.D., chief science officer of Applied Proteomics,noted in a statement.
 
 
The partnership comes just a few weeks after Agilentannounced another mass spectrometry-based agreement with Florida InternationalUniversity. The company will be collaborating with the University's departmentof chemistry and biochemistry and its International Forensics ResearchInstitute to advance approaches for identifying and characterizing designerdrugs. Agilent and Florida International University will seek to develop andvalidate new methods for rapid forensic screening and analysis utilizingadvanced chromatography and mass-spectrometry systems such as LC-QQQ-MS/MS,LC-QTOF-MS, GC/MS and GC/MS/MS.
 
 
Designer drugs consist of novel analogs or derivatives ofunlawful drug compounds synthesized to mimic illegal recreational drugs, andinclude classes such as phenethylamines, cathinones, tryptamines, piperazinesand synthetic cannabinoids.
 
"Since routine immunoassay drug-screening methods are unableto detect most of the hundreds of individual designer drugs that have been identified,we are working with Agilent to develop advanced analytical methods to screenand confirm the presence of such drugs in both ante- and post-mortemspecimens," Dr. Anthony DeCaprio, associate professor and director of theForensic & Analytical Toxicology facility at Florida InternationalUniversity's International Forensic Research Institute, said in a press releaseregarding the collaboration. "Recently, we validated a method for the detectionand quantification of 32 designer drugs in serum, including 24 phenethylamines,four piperazines and four tryptamines. In collaboration with Agilent, we willcontinue to expand our tandem mass-spectral library to approximately 300designer drugs."
 
 
 
 
 
SOURCE: Agilent press release

About the Author

Related Topics

Loading Next Article...
Loading Next Article...
Subscribe to Newsletter

Subscribe to our eNewsletters

Stay connected with all of the latest from Drug Discovery News.

Subscribe

Sponsored

Laboratorian with a white coat and blue gloves pipettes green liquid into a beaker with multicolored liquids in beakers and tubes in the blue-tinged, sterile laboratory background.

Discovering cutting-edge nitrosamine analysis in pharmaceuticals

New tools help researchers detect and manage harmful nitrosamine impurities in drugs such as monoclonal antibodies.
A starry night sky reflected over calm water, symbolizing the discovery of hidden patterns in complex systems.

Technology Guide: Spatial biology techniques

Discover essential strategies and expert insights to navigate the expanding world of spatial biology.
Red tumor cells are shown against a teal backdrop showing attachment to tissue.

Decoding the tumor microenvironment with immune profiling

Integrating multiplexed immunohistochemistry with spatial analysis offers a practical way to uncover tumor-immune dynamics.
Drug Discovery News March 2025 Issue
Latest IssueVolume 21 • Issue 1 • March 2025

March 2025

March 2025 Issue

Explore this issue