Genome-wide CRISPR screening has transformed the study of gene function, but conventional approaches often miss spatial aspects of cellular behavior. Image-enabled cell sorting addresses this by linking genetic perturbations to visual phenotypes such as protein localization. In models of dilated cardiomyopathy, this enables deeper insight into the genetic regulators of nuclear transport.
Download this article to learn:
- How image-enabled cell sorting connects visual phenotypes with CRISPR perturbations at scale
- How spatial features like protein localization can be used to isolate and analyze distinct cell populations
- How this approach identified regulators of protein localization in a cardiomyopathy model
