2007 DDT New Product Showcase

The New AccuSampler Micro is uniquely adapted for low-volume sampling over the range of 5 to 100 µL. The system eliminates the "borrowing" of blood from the animal, which can disrupt normal physiology and induce shock in a mouse. A PK study can be done in one animal whereas manual methods typically require three animals for one data point.

Assay all three PPAR isoforms with Invitrogen's LanthaScreen competitive binding assays. This proven format reduces hands-on time and experimental variables typical to radioligand-binding assays, since no centrifugation, filtration or washing steps are needed. Assays are optimized for stability and robustness, ensuring successful screening projects.

Nunc LiveCell Array is the first slide-based tool that enables multiplex, real-time cellular assays on thousands of individual living cells, either adherent or non-adherent. The technology utilizes tiny cell-sized "pico-wells", which can assign an individual address to each cell using industry-standard microscopes and imaging software. Real-time kinetic assays on suspension cells are now a reality.

The Transfluor technology is a patented, universal GPCR drug discovery technology designed for screening potential drug candidates against all GPCR targets, whether they are known or orphan.  The Transfluor assay works regardless of the specific second messenger coupling to the GPCR. The technology is imaging-based and utilizes redistribution of a GFP-tagged protein (GFP) called "beta-arrestin" which monitors GPCR activation and internalization.

BioBook simplifies the management of complex research data, enhancing the productivity of biologists by providing a compliant flexible environment that controls every stage of the study lifecycle. From organizing and designing experiments and capturing data, to generating and sharing reports, BioBook offers a complete, robust and easy-to-use data management solution geared to the specific needs of the research biologist.

The new Omega series of four fully upgradeable multifunctional readers which offer high-resolution spectro-meter-based absorbance. The Omega microplate readers are the world's first multifunctional readers capable of capturing a full absorbance spectrum (220-850 nm) in 1 second per well, at a resolution of 1 nm.

This valuable 84-page publication describes the principles behind HuCAL recombinant antibodies, the basis of their exceptional specificity, and presents protocols, examples, and troubleshooting tips for their use in applications such as Western blotting, ELISA, IHC, IP and flow cytometry. This essential publication for all antibody users will be available from AbD Serotec (Booth 807) at DDT 2007.

IonGate Biosciences launches the next generation of its unique biosensor technology SURFE2R (SURFace Electrogenic Event Reader). Characterized by a distinctive higher throughput, the newly introduced SURFE2R Workstation is of particular interest for pharmaceutical drug discovery, enabling efficient drug screening with the important target classes of ion transporters and channels.

Siemens' newest preclinical solution, Inveon, is a modular concept that offers complete flexibility, enabling PET, SPECT, and CT data acquisition, and provides the industry's highest PET resolution and sensitivity. Inveon's suite of research tools can help facilitate basic research, as well as the drug development process, empowering researchers to identify specific biological processes, monitor the efficacy of compounds, and measure the effects of disease progression over time.

The Tripos Chemistry Extensions package introduces chemical-intelligence to the highly extensible KNIME platform, providing researchers with the functionality to manipulate, analyze, and visualize chemical data in an open-source workflow environment. Tripos provides support not only for the Tripos Chemistry Extensions package and the Tripos technologies embedded within, but also provides support options for the open-source KNIME platform itself.

The Hudson SOLO is a low-cost, high-throughput single-channel pipettor able to perform DNA transformations, cherry picking, and other applications involving the transfer of liquid samples. Equipped with a broad dynamic volume range and the ability to handle reactions in a sterile environment, the SOLO can be loaded and operated manually, but is also compatible with robot loading systems from most manufactures, including the Hudson PlateCrane EX.

The Agencourt RNAdvance Tissue extraction kit offers drug development researchers an automated walk-away solution for consistent recovery of high-quality total RNA in a multi-well format.  Utilizing patented SPRI technology on Beckman Coulter instrumentation, this system can extract total RNA from a wide variety of tissues for downstream applications, such as gene expression, without needing centrifugation or vacuum filtration.

Pathway Studio Enterprise retrieves biological meaning from gene expression and other high-throughput dataand to build and analyze pathways. Powerful methods for microarray data analysis include Gene Set Enrichment Analysis (GSEA) with an ability to build custom ontologies. MedScan module allows to process the literature and create custom databases.

The ZeptoMARK reverse array is a system to quantitatively measure drug on- and off-target effects in cells and to evaluate biomarker candidates and drug effects in tissues. The innovative reverse-phase arrays have been expanded to evaluate and determine biomarkers in urine. See us at booth # 946 and learn how you can profit from Zeptosens technology and services.

The CytoTox-Glo Cytotoxicity Assay is a single-reagent addition, homogeneous, luminescent assay that measures the number of dead cells in cell populations. The assay, which measures a distinct protease substrate from cells that have lost their membrane integrity, exhibits excellent correlation with other methods of assessing cell viability. CytoTox-Glo Cytotoxicity Assay is ideal for high-throughput screening applications.

The Maybridge Ro3 Fragment Library is specifically designed and computationally clustered to provide a rich source of optimizable hits for your fragment screening programs.  Rigorous pre-filtering and application of standard Daylight fingerprint algorithms has resulted in a library of 1,000 desirable fragments of quantifiable structural diversity and complete Rule of Three compliance.  This offering provides a convenient and cost effective source of pre-selected high quality fragments, weighed and packed to your specific requirements.

CombiFlash Rf from Teledyne Isco purifies samples from 4 mg through 35 g, with programmable selection from 4 solvents for quick changeover between normal- and reversed-phase separations. Method automation via RFID (radio frequency identification) reduces setup time and errors. Space-saving design uses the least bench/hood space of any automated flash chromatography system. Solvent delivery to 200 PSI allows for greater flexibility in solvent choice.

The Transcreener UGT far red-assay is a fluorescence polarization immunoassay that detects UDP, the common reaction product formed during the transfer of a sugar moiety from the donor (UDP-sugar) to an acceptor substrate. The far-red format demonstrates utility in both purified and human liver microsome environments, provides greater sensitivity for enhanced mP shifts, and minimizes compound fluorescence interference issues.  BellBrook Labs offers an expanding drug discovery product line that currently includes assays for the detection of ADP, AMP, GMP, and UGT.

TissueMine is a Web-based digital pathology solution that automates studies of tissue samples for research and development. It is an affordable, effective, complete solution for acquisition, analysis, management, reporting and sharing of tissue images. It includes the iScan—160 slide capacity scanner with 20x and 40x resolution. TissueMine includes comprehensive algorithms for rapid image analysis of tissue microarrays (TMA) and whole-tissue slides.

Introducing our newest technology; the BioStation CT is an integrated tissue culture incubator, microscope and digital image acquisition system designed for live cell tracking.  It provides a system for managing, observing, and documenting cultured cells in a secure and optimized environment.  Easy to use, it provides outstanding phase contrast and three channel fluorescence imaging from 2X to 40X magnifications.

The Human Genome-Wide SPLICEARRAY monitors over 23,000 human genes covering over 130,000 expressed transcripts and requires over 6 million probes. This new design, manufactured on the Affymetrix platform, provides researchers the opportunity to obtain gene expression results on a single microarray by interrogating both exons and splice junctions.