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Stanford researchers find protein targets for treating MS
March 2008
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STANFORD, Calif.óResearchers from the Stanford University School of Medicine have identified therapy targets that could lead to personalized treatments for patients at each phase of multiple sclerosis by essentially cataloging all of the brain-tissue proteins that they found were distinct to three discrete stages of the disease. "This is a gold mine," says Dr. Lawrence Steinman, professor of neurology and neurological sciences. "Knowing what proteins are most important at a discrete stage of the multiple sclerosis process is the first step toward being able to 'personalize' treatment."
In the study, the team found many unexpected proteins involved in the disease progression. When they tested drugs that block two of these proteins in a mouse model of multiple sclerosis, the mice improved dramatically. 

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