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Catching something good with QTRAP
March 2011
by Jeffrey Bouley  |  Email the author


FOSTER CITY, Calif.—Global life science analytical technologies company AB SCIEX has entered into a collaboration with Salt Lake City-based ARUP Laboratories, a major clinical reference laboratory in the United States, to develop new test methods for clinical research laboratories to consider adopting to improve hormone analysis.
To do this, ARUP researchers are using AB SCIEX QTRAP 5500 mass spectrometry technology to obtain results that the two companies say were previously unavailable to clinical researchers and will "help deliver better answers that can be used to improve healthcare. "  
According to AB SCIEX, forging a collaboration with a leading clinical reference laboratory is a conscious decision to help further drive an industry-wide move toward increased use of mass spectrometry to conduct hormone analysis.
"The shift to mass spectrometry-based clinical research continues to rapidly accelerate. To have a leading clinical reference laboratory such as ARUP Laboratories utilize QTRAP technology for method development reinforces the importance of high sensitivity that AB SCIEX technology delivers," says Joe Anacleto, vice president and general manager of the Applied Markets and Clinical Research Business of AB SCIEX. "By being a trusted partner with clinical researchers, AB SCIEX is able to make it easier for laboratories to adopt mass spectrometry and obtain better answers."
Because many hormones exist in extremely low abundance, immunoassay-based approaches are often plagued by interferences, preventing them from obtaining accurate measurements, AB SCIEX and ARUP note. To address this challenge, ARUP turned to QTRAP technology to obtain a higher level of sensitivity, which is needed to perform the most accurate quantitation of low abundant hormones, especially free hormones, while confirming the results with qualitative capabilities within the same system.  
"Our mission in the mass spectrometry lab of ARUP is to push the limits of quantitation as low as we can, so we can deliver better results for clinical research," says Dr. Alan Rockwood, scientific director of the Mass Spectrometry Lab at ARUP Laboratories. "Our collaboration with AB SCIEX, whose scientists have taken the time to understand our stringent requirements, gives us access to mass spectrometry technology that helps us to fulfill our purpose. By providing more accurate answers than previously possible, we are supporting efforts to improve medical care."  
AB SCIEX provides what it maintains is the highest-sensitivity instrumentation on the market today as part of a simple, four-step workflow for mass spectrometry-based clinical research. The AB SCIEX QTRAP 5500 System combines high sensitivity and speed on a platform that integrates quantitative and qualitative analysis, representing a "better type of triple quadrupole," the company says.
In collaboration with AB SCIEX scientists, ARUP researchers are using this technology to develop new test methods that AB SCIEX plans to turn into preconfigured iMethod tests available for download into AB SCIEX Cliquid Software, which is an application that is said to significantly simplify the use of advanced mass spectrometry technology for clinical research.  
AB SCIEX's senior product manager for the clinical products, Lisa Sapp, tells ddn that the collaboration is expected to conclude in about a year, but could not share any details about possible cost or even pricing ranges for the iMethods Test that would be generated from this collaboration, saying, "Nothing has been decided yet."  
As for how the companies came together on this project, Sapp says, "ARUP has been a longtime customer of AB SCIEX.  Both companies have an interest in helping people realize the benefits of LC MS MS for clinical research."  

AB Sciex and GeneBio enhance library searching for mass spec

GENEVA, Switzerland—AB SCIEX also recently teamed up with Geneva Bioinformatics SA (also known as GeneBio) to co-market joint solutions to improve the ability of scientists to conduct rapid screening of large sets of molecules.  
According to the companies, GeneBio's SmileMS software provides advanced library searching capabilities that can be used with AB SCIEX's mass spectrometers and software applications. SmileMS can be used with the broad range of AB SCIEX systems, including triple quadrupole and QTRAP systems, as well as the new TripleTOF 5600 System.
These solutions are already being used for both targeted and unknown screening in numerous fields, but Joe Anacleto, vice president and general manager of AB Sciex's Applied Markets and Clinical Research business, says that together, they can enhance the identification and visualization of analytes.
"We continue to provide added value to our customers by working with companies like GeneBio," Anacelto says. "We believe the integration of SmileMS with our industry-leading systems will create new opportunities to improve results in clinical and forensic toxicology, among other fields that can take advantage of these capabilities."  
Nasri Nahas, CEO of GeneBio, adds: "AB SCIEX customers will have the advantage of using the best-in-class capabilities of SmileMS software for the identification of small molecules by mass spectrometry for fast routine analysis and in-depth research. We are extremely pleased to partner with AB SCIEX, a global leader in mass spectrometry technologies that has set the tone for innovation in this field. This relationship helps us to focus our efforts and expertise on software development to continue serving our customers' needs with powerful solutions. "
Financial details of the partnership were not released.
Code: E031111



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