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Lots of attention for ADHD
December 2012
SHARING OPTIONS:
NEW YORK—Pfizer Inc. has announced its intent to acquire
Cupertino, Calif.-based NextWave Pharmaceuticals, a privately held specialty
pharmaceutical company specializing in developing products for the treatment of
attention deficit hyperactivity disorder (ADHD) and related central nervous
system disorders.
The two companies had previously entered into an option and
merger agreement during the second quarter of the year, during which Pfizer
made an option payment to NextWave of $20 million. Pfizer is now exercising its
option to acquire NextWave. Per the terms of the agreement, Pfizer will pay
NextWave’s shareholders $255 million at the close of the transaction, and the
shareholders will also be eligible to receive up to an additional $425 million
if certain sales milestones are met.
“NextWave has been focused on helping patients and families
who struggle with the challenges of ADHD,” Jay P. Shepard, president and CEO of
NextWave, said in a press release. “We are excited to partner with Pfizer, one
of the most respected pharmaceutical organizations in the world, to bring the
unique benefits of Quillivant XR to those affected by this challenging
condition.”
Quillivant XR for extended-release oral suspension, CII, is
the first once-daily liquid medication approved for the treatment of ADHD in
the United States. Quillivant XR was developed by NextWave in collaboration
with Tris Pharma, NextWave’s technology and manufacturing partner, and was
developed on Tris Pharma’s OralXR+ platform. NextWave holds exclusive North
American commercialization rights to the drug, which gained U.S. Food and Drug
Administration approval on Sept. 27. The medication is expected to reach
pharmacy shelves in January 2013.
NextWave could not be reached for additional comments on the
acquisition, and Pfizer declined to provide an interview on the transaction at
present.
NextWave’s pipeline currently contains another potential
ADHD treatment, NWP09. The compound, indicated for ADHD, is a Methylphenidate
extended-release chewable tablet, and is currently in Phase III
development. NWP09 is undergoing a Phase
III multicenter, double-blind, randomized, placebo-controlled clinical trial
for the evaluation of its effectiveness in children with ADHD ages six years to
12 years. The company has a target date of 2013 for a New Drug Approval
submission.
“This agreement demonstrates our focused expansion of the
Established Products U.S. brands business to offer a diverse portfolio of
high-quality medicines that meet patients’ needs,” said Albert Bourla,
president and general manager in Pfizer’s Established Products business unit,
in a statement. “By combining the advantages of Quillivant XR with Pfizer’s
commercialization expertise, we will be able to provide ADHD patients and their
caregivers a new treatment option.”
ADHD currently stands as one of the most common neurobehavioral
disorders in the United States, and is characterized by marked difficulty
paying attention, impulsive behavior and, in some cases, being overly active.
In a 2009 report from the Centers of Disease Control and Prevention,
approximately one in 10 children (9.5 percent) ages 4 to 17 in the United
States have received a diagnosis of ADHD. The condition often continues into
adulthood, and roughly 4 percent of Americans are believed to be affected with
adult ADHD.
In a report released by GlobalData in October 2011,
“Attention Deficit Hyperactivity Disorder (ADHD) Therapeutic: Pipeline
Assessment and Market Forecasts to 2018,” the firm noted that the global ADHD
therapeutics market had a value of approximately $3.8 billion in 2010, and is
expected to grow at a compound annual growth rate of 8 percent over the next
eight years, reaching roughly $7.1 billion by 2018.
The transaction is expected to close in the fourth quarter
of this year, and is subject to customary closing conditions, including
regulatory approval in the United States. No details were provided as to
Pfizer’s plans for NextWave’s facilities or employees following the
acquisition.
Pfizer brought on Jefferies & Company Inc. as its financial advisor
for the transaction, and Pfizer Legal Alliance firms Kaye Scholer LLP and Ropes
& Gray LLP were brought on as legal counsel. NextWave brought on Aquilo
Partners LP as its financial advisor, while Cooley LLP served as the company’s
legal advisor. Code: E121201 Back |
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