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CoMMpass to multiple myeloma treatment
August 2012
SHARING OPTIONS:
NORWALK, Conn.—The Multiple Myeloma Research Foundation
(MMRF) has announced a partnership with US Oncology Research to undertake a
landmark, long-term clinical study of multiple myeloma’s (MM) natural history
and its effects on the body at the molecular level.
MM is an incurable cancer of the blood. An estimated 20,000
new cases are diagnosed every year, and close to 100,000 patients are currently
living with the disease.
According to Dr. Robert Rifkin, oncologist and hematologist
at Rocky Mountain Cancer Centers, which is affiliated with US Oncology
Research, 20 years ago, survivability among those diagnosed with multiple
myeloma was very poor—perhaps two to three years.
“Fortunately, during the past couple of decades, we’ve
gained access to a host of new agents, including proteasome drug classes and
stem cell transplants,” he says. “We’ve improved patient survivability to 10 years
or more in some cases.”
Medical science still has a long way to go, however. It has
yet to be able to fully analyze the natural history of MM. Part of what makes
the disease so difficult to understand and treat is the fact that it arises
from multiple malignancies rather than from a single illness or event—for
example, toxic exposure followed by an infection. The combination of factors
leading to the development of the illness varies from patient to patient,
making a one-size-fits-all therapy that much more difficult to isolate.
Instead of looking for a single new therapy, this
collaboration between MMRF and US Oncology Research will be a foray into
personalized medicine, with the hope of learning the molecular and genetic
changes that mark the progression of the disease and discovering ways to cater
treatment to each individual case. This landmark study has been dubbed Relating
Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic
Profile, or CoMMpass, and is supported by a $40 million investment by the MMRF.
“This study is really a prototype of personalized medicine,”
says Dr. Carolyn Hoban, director of translational research at MMRF. “The
results may someday empower physician’s decision-making regarding treatment
options for their patients.”
“Our goal is to accrue 1,000 newly diagnosed multiple
myeloma patients and to use genome sequencing to identify new targets for
therapy, which could potentially lead to the development of a new drug,” says
Rifkin. “We would then be able to take it through development. We plan to
follow the patients for a minimum of five years.”
At the outset, newly diagnosed MM patients’ tissues will be
analyzed for quality and whole-genome sequencing. Their chromosomes will be
analyzed, and DNA and RNA samples will be extracted as they begin therapy.
Researchers will be able to observe these patients going forward and return
information in real-time, both to the doctors and to the patients. Finally,
additional sets of tissue samples will be taken at each relapse and at the time
of failure of treatment, providing benchmarks that will allow researchers to
observe the molecular-level changes that have occurred during the course of the
disease.
The study also aims to create a “biobank” of serum and
plasma that can be further analyzed to look for better biomarkers to facilitate
new diagnostic and treatment options in future patients.
“We hope to discover more noninvasive diagnostic tools that
will minimize the discomfort to the patient,” Hoban says.
The collaboration between MMRF and US Oncology Research
marries two robust partners in the fight against multiple myeloma. US Oncology
Research represents a large community of MM patients and physicians, as the
organization sees roughly 20 percent of all new MM cases, and has participated
in 38 out of 40 U.S. Food and Drug Administration (FDA)-approved drugs. US
Oncology Research is already currently involved in about 100 other open trials,
and will be the principal investigator overseeing the CoMMpass study. Aside from
financial sponsorship of the CoMMpass study, the Multiple Myeloma Research
Foundation brings to the table the technology and the science necessary to
process the tissue samples and conduct the genome sequencing and other
molecular analyses.
The CoMMpass study already has two pharmaceutical
partners—Millennium and Onyx—that, in exchange for financial support of the
study, will receive priority access to the data it generates for a six-month
window, after which the data will enter the public domain. Two or three
additional pharmaceutical partners may be added to the study later.
“Our hope is that we will quickly begin generating
hypotheses that can lead to clinical trials,” says Anne Quinn Young, vice
president of marketing at MMRF. “We’re in a position to play a lead role in
connecting this data to therapeutic advances.”
“We need more collaborations like this between the medical
and patient communities and academia,” Rifkin says. “We’re off to a good
start.” Code: E081222 Back |
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