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Novel peptide delivery system for dsRNA
September 2009
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Integrated DNA Technologies  
 
Integrated DNA Technologies (IDT), a specialist in oligonucleotide synthesis, has introduced the novel, peptide-based, double-stranded RNA (dsRNA) transduction delivery system Transductin. Developed by Dr. Steven Dowdy's lab at the UCSD School of Medicine, Transductin is a small fusion protein comprised of multiple Peptide Transduction Domains connected to a Double-Stranded RNA Binding Domain (PTD-DRBD). The DRBD domain binds the RNA duplex and serves to keep the positively charged PTD away from the negatively charged RNA, maximizing potency of the peptide transduction domain. Licensed from Traversa Therapeutics for research applications, Transductin is intended for in vitro testing and high-throughput screening projects. Transductin complexes with dsRNAs, such as IDT's Dicer-substrate siRNAs, and delivers them across cell membranes via macropinocytosis. This mechanism minimizes the risk of having the dsRNA trigger an innate immune response and has virtually no toxicity, which are common drawbacks when using cationic lipid transfection, which are common drawbacks when using cationic lipid transfection.
 
Integrated DNA Technologies
(800) 328-2661
 

 

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