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HPLC columns for synthetic oligonucleotides
Phenomenex Inc. introduces Clarity Oligo-RP Columns for the reversed phase purification of oligonucleotides with balanced hydrophobicity and polar selectivity. Ideal for trityl-off purification of DNA, RNA and modified or labeled oligos, the new columns easily separate full-length oligos from N-1 and other failed sequences. The specially designed Oligo-RP media, based on Phenomenex's proprietary TWIN (two in one) composite particle technology, recognizes minute differences in interaction features of two oligos, providing better resolution than other methods. Oligo-RP columns perform at 90 percent or higher purity levels with typical recovery rates of 70 percent. The Oligo-RP phase allows high loadability and delivers high recovery and purity while eliminating the need for an extra desalting step. The new Oligo-RP columns are part of Phenomenex's Clarity BioSolutions portfolio of products for synthetic oligonucleotide purification. Clarity Oligo-RP columns have loading capacities from 50 nmole to 50 Ámole and are offered in sizes for analytical, semi-preparative and preparative applications.