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HT drug metabolism enzyme assay, Bellbrook Labs
May 2005
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BellBrook Labs has released a new product for evaluating drug efficacy and safety. The Transcreener(tm) UGT Assay is a universal UDP glucuronosyl-transferase (UGT) assay, which enables screening of all UGT isoforms and diverse acceptors using the same assay and reagents, because it relies on detection of the invariant reaction product, UDP.
 
A broad spectrum of drugs, including opioids, steroidal anti-inflammatories, and antidepressants, are eliminated or activated in the body by glucuronidation. This robust fluorescence polarization assay measures UDP formed during UGT-catalyzed glucuronidation reactions. It is a homogenous "mix-and-read" assay, and was developed for high-throughput applications in order to facilitate the evaluation of thousands of compounds on a daily basis.
 
Bellbrook Labs
www.bellbrooklabs.com

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