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Research reinforces link between gut microbiome and autism
June 2018
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BOSTON & PASADENA, Calif.—Axial Biotherapeutics shared data at the recent International Society for Autism Research conference regarding the link between the gut microbiome and autism spectrum disorder (ASD). Axial found that concentrations of 4-ethylphenylsulfate (4-EPS), a bacterial metabolite, were as much as sixfold higher in serum samples from children with ASD compared to healthy controls in replicate analyses. Previous work by Dr. Sarkis Mazmanian, co-founder of Axial, demonstrated causality between 4-EPS and anxiety-like behaviors in a “maternal immune activation” mouse model of ASD.
 
“Our clinical biomarker results, derived from one of the largest ASD serum metabolomics studies conducted to date, are encouraging,” said Axial co-founder and CEO Dr. David H. Donabedian. “These data, which are the first we have presented from our ASD program, present a major advancement in our mission to develop microbiome-inspired therapeutics as a potential new approach to treating neurological diseases and disorders like ASD.”

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